The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia - PubMed (original) (raw)
Comment
The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia
Kathryn V Holmes et al. mBio. 2013.
Abstract
A new human betacoronavirus in lineage c, tentatively called HCoV-EMC, was isolated from a patient from the Kingdom of Saudi Arabia who died from acute severe pneumonia and renal failure. The viral RNA has been detected in eight additional cases. Sequencing and bioinformatic analysis of the viral genomic RNA showed that it is a novel virus not previously detected in any other species and that its closest relatives are two Asian bat coronaviruses. HCoV-EMC may represent a sporadic spillover to humans from an unknown animal reservoir. In a recent article, van Boheemen et al. demonstrated how state-of-the-art sequencing technology and bioinformatic analysis can quickly provide critical insight into the viral genome sequence, phylogeny, replication strategy, and potential drug and vaccine targets and generate tools to evaluate the possible epidemic risk associated with this novel human virus.
Comment on
- Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans.
van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA. van Boheemen S, et al. mBio. 2012 Nov 20;3(6):e00473-12. doi: 10.1128/mBio.00473-12. mBio. 2012. PMID: 23170002 Free PMC article.
Similar articles
- Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans.
van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA. van Boheemen S, et al. mBio. 2012 Nov 20;3(6):e00473-12. doi: 10.1128/mBio.00473-12. mBio. 2012. PMID: 23170002 Free PMC article. - Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Zaki AM, et al. N Engl J Med. 2012 Nov 8;367(19):1814-20. doi: 10.1056/NEJMoa1211721. Epub 2012 Oct 17. N Engl J Med. 2012. PMID: 23075143 - Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?
Chan JF, Li KS, To KK, Cheng VC, Chen H, Yuen KY. Chan JF, et al. J Infect. 2012 Dec;65(6):477-89. doi: 10.1016/j.jinf.2012.10.002. Epub 2012 Oct 13. J Infect. 2012. PMID: 23072791 Free PMC article. Review. - Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus.
Cotten M, Lam TT, Watson SJ, Palser AL, Petrova V, Grant P, Pybus OG, Rambaut A, Guan Y, Pillay D, Kellam P, Nastouli E. Cotten M, et al. Emerg Infect Dis. 2013 May;19(5):736-42B. doi: 10.3201/eid1905.130057. Emerg Infect Dis. 2013. PMID: 23693015 Free PMC article. - Properties of Coronavirus and SARS-CoV-2.
Malik YA. Malik YA. Malays J Pathol. 2020 Apr;42(1):3-11. Malays J Pathol. 2020. PMID: 32342926 Review.
Cited by
- Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus.
Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F. Chen Y, et al. J Virol. 2013 Oct;87(19):10777-83. doi: 10.1128/JVI.01756-13. Epub 2013 Jul 31. J Virol. 2013. PMID: 23903833 Free PMC article. - The amino acids 736-761 of the MERS-CoV spike protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agents.
Yang Y, Deng Y, Wen B, Wang H, Meng X, Lan J, Gao GF, Tan W. Yang Y, et al. Viral Immunol. 2014 Dec;27(10):543-50. doi: 10.1089/vim.2014.0080. Viral Immunol. 2014. PMID: 25387086 Free PMC article. - Lysosomal Proteases Are a Determinant of Coronavirus Tropism.
Zheng Y, Shang J, Yang Y, Liu C, Wan Y, Geng Q, Wang M, Baric R, Li F. Zheng Y, et al. J Virol. 2018 Nov 27;92(24):e01504-18. doi: 10.1128/JVI.01504-18. Print 2018 Dec 15. J Virol. 2018. PMID: 30258004 Free PMC article. - Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus.
Yang Y, Du L, Liu C, Wang L, Ma C, Tang J, Baric RS, Jiang S, Li F. Yang Y, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12516-21. doi: 10.1073/pnas.1405889111. Epub 2014 Aug 11. Proc Natl Acad Sci U S A. 2014. PMID: 25114257 Free PMC article. - Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
Yang Y, Liu C, Du L, Jiang S, Shi Z, Baric RS, Li F. Yang Y, et al. J Virol. 2015 Sep;89(17):9119-23. doi: 10.1128/JVI.01279-15. Epub 2015 Jun 10. J Virol. 2015. PMID: 26063432 Free PMC article.
References
- Li W, et al. 2005. Bats are natural reservoirs of SARS-like coronaviruses. Science 310:676–679 - PubMed
- Woo PC, et al. 2012. Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J. Virol. 86:3995–4008 - PMC - PubMed
- Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. 2012. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl J. Med. 367:1814–1820 - PubMed
- World Health Organization Global Alert and Response Background and summary of novel coronavirus infection—as of 21 December, 2012. http://www.who.int/csr/disease/coronavirus_infections/update_20121221/en... .
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources