Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1 - PubMed (original) (raw)
. 2013 Jan 9;77(1):70-82.
doi: 10.1016/j.neuron.2012.11.009.
Elke Stappers, Bram Vandesande, Jordane Dimidschstein, Roel Kroes, Annick Francis, Andrea Conidi, Flore Lesage, Ruben Dries, Silvia Cazzola, Geert Berx, Nicoletta Kessaris, Pierre Vanderhaeghen, Wilfred van Ijcken, Frank G Grosveld, Steven Goossens, Jody J Haigh, Gord Fishell, André Goffinet, Stein Aerts, Danny Huylebroeck, Eve Seuntjens
Affiliations
- PMID: 23312517
- DOI: 10.1016/j.neuron.2012.11.009
Free article
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1
Veronique van den Berghe et al. Neuron. 2013.
Free article
Abstract
GABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the embryonic ventral telencephalon (VT) and migrate tangentially to the cortex, guided by membrane-bound and secreted factors. We found that Sip1 (Zfhx1b, Zeb2), a transcription factor enriched in migrating cortical interneurons, is required for their proper differentiation and correct guidance. The majority of Sip1 knockout interneurons fail to migrate to the neocortex and stall in the VT. RNA sequencing reveals that Sip1 knockout interneurons do not acquire a fully mature cortical interneuron identity and contain increased levels of the repulsive receptor Unc5b. Focal electroporation of Unc5b-encoding vectors in the MGE of wild-type brain slices disturbs migration to the neocortex, whereas reducing Unc5b levels in Sip1 knockout slices and brains rescues the migration defect. Our results reveal that Sip1, through tuning of Unc5b levels, is essential for cortical interneuron guidance.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment in
- A sip of GABA for the cerebral cortex.
Tomassy GS, Lodato S, Arlotta P. Tomassy GS, et al. Neuron. 2013 Jan 9;77(1):1-3. doi: 10.1016/j.neuron.2012.12.026. Neuron. 2013. PMID: 23312509 - Epilepsy in Mowat-Wilson syndrome: is it a matter of GABA?
Cordelli DM, Pellicciari A, Kiriazopulos D, Franzoni E, Garavelli L. Cordelli DM, et al. Epilepsia. 2013 Jul;54(7):1331-2. doi: 10.1111/epi.12204. Epilepsia. 2013. PMID: 23815573 No abstract available.
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