The heritability of human disease: estimation, uses and abuses - PubMed (original) (raw)
Review
doi: 10.1038/nrg3377.
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- PMID: 23329114
- DOI: 10.1038/nrg3377
Review
The heritability of human disease: estimation, uses and abuses
Albert Tenesa et al. Nat Rev Genet. 2013 Feb.
Abstract
Relatives provide the basic material for the study of inheritance of human disease. However, the methodologies for the estimation of heritability and the interpretation of the results have been controversial. The debate arises from the plethora of methods used, the validity of the methodological assumptions and the inconsistent and sometimes erroneous genetic interpretations made. We will discuss how to estimate disease heritability, how to interpret it, how biases in heritability estimates arise and how heritability relates to other measures of familial disease aggregation.
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