Role of phyto-oestrogens in ovulation induction in women with polycystic ovarian syndrome - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.1016/j.ejogrb.2012.12.025. Epub 2013 Jan 21.
Affiliations
- PMID: 23347605
- DOI: 10.1016/j.ejogrb.2012.12.025
Randomized Controlled Trial
Role of phyto-oestrogens in ovulation induction in women with polycystic ovarian syndrome
Hany H Kamel. Eur J Obstet Gynecol Reprod Biol. 2013 May.
Retraction in
- Retraction notice to 'Role of phyto-oestrogens in ovulation induction in women with polycystic ovarian syndrome' [Eur. J. Obstet. Gynecol. Reprod. Biol. 168 (2013) 60-63].
Kamel HH. Kamel HH. Eur J Obstet Gynecol Reprod Biol. 2023 Dec;291:212. doi: 10.1016/j.ejogrb.2023.09.027. Epub 2023 Nov 1. Eur J Obstet Gynecol Reprod Biol. 2023. PMID: 37922774 No abstract available.
Abstract
Objective: To study the role of a phyto-oestrogen, Cimicifuga racimosa extract (Klimadynon(®), Bionorica, Neumarkt i.d.OBf., Germany), in ovulation induction in women with polycystic ovarian syndrome (PCOS).
Study design: Prospective randomized controlled trial in Minia University Hospital, Minia, Egypt. One hundred women with PCOS were allocated into one of two groups: one group (n=50) received clomiphene citrate 100mg daily for 5 days, and the other group (n=50) received C. racimosa 20mg daily for 10 days. Both groups received medication starting from the second day of the cycle for three consecutive cycles, during which changes in follicle-stimulating hormone (FSH), luteinizing hormone (LH), FSH/LH ratio, progesterone, endometrial thickness and pregnancy rate were measured.
Results: The groups were similar in terms of age, clinical presentation and hormonal levels before treatment. Following treatment, significant favourable changes in LH level and FSH/LH ratio (p=0.007 and 0.06, respectively) were seen in the Klimadynon group. In this group the progesterone level was higher from the first treatment cycle, indicating better ovulation (p=0.0001), and endometrial thickness was greater (p=0.0004). The pregnancy rate was higher in the Klimadynon group but the difference between the groups was not significant (p=0.1).
Conclusion: Phyto-oestrogen can be used as an alternative to clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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