Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin - PubMed (original) (raw)

Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin

Tomita Vasilica Stirbat et al. PLoS One. 2013.

Abstract

What governs tissue organization and movement? If molecular and genetic approaches are able to give some answers on these issues, more and more works are now giving a real importance to mechanics as a key component eventually triggering further signaling events. We chose embryonic cell aggregates as model systems for tissue organization and movement in order to investigate the origin of some mechanical constraints arising from cells organization. Steinberg et al. proposed a long time ago an analogy between liquids and tissues and showed that indeed tissues possess a measurable tissue surface tension and viscosity. We question here the molecular origin of these parameters and give a quantitative measurement of adhesion versus contractility in the framework of the differential interfacial tension hypothesis. Accompanying surface tension measurements by angle measurements (at vertexes of cell-cell contacts) at the cell/medium interface, we are able to extract the full parameters of this model: cortical tensions and adhesion energy. We show that a tunable surface tension and viscosity can be achieved easily through the control of cell-cell contractility compared to cell-medium one. Moreover we show that α-catenin is crucial for this regulation to occur: these molecules appear as a catalyser for the remodeling of the actin cytoskeleton underneath cell-cell contact, enabling a differential contractility between the cell-medium and cell-cell interface to take place.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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References

    1. Foty RA, Pfleger C, Forgacs G, Steinberg MS (1996) Surface tensions of embryonic tissues predict their mutual envelopment behavior. Development 122: 1611. - PubMed
    1. Foty RA, Forgacs G, Pfleger C, Steinberg MS (1994) Liquid properties of embryonic tissues: measurement of interfacial tensions. Physical review letters 72: 2298–2301. - PubMed
    1. Steinberg MS (1963) Reconstruction of tissues by dissociated cells. Some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. Science 141: 401–408. - PubMed
    1. Steinberg MS, Takeichi M (1994) Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc Natl Acad Sci U S A 91: 206–209. - PMC - PubMed
    1. Foty RA, Steinberg MS (2005) The differential adhesion hypothesis: a direct evaluation. Developmental biology 278: 255–63. - PubMed

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This work was supported by Agence Nationale de la Recherche (ANR JCJC 2005). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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