X and Y chromosome complement influence adiposity and metabolism in mice - PubMed (original) (raw)

Body weight change, food consumption, body temperature, and glucose tolerance of mice in cross C (XY* model) after eating an HFD for 16 weeks. A, In the first 3 days and nights of the HFD, the amount of weight gain correlated with the number of sex chromosomes (1-way ANOVA, 1 vs 2 vs 3 non-PAR regions of sex chromosomes, F(2,48) = 3.64, P < .033). XXY mice gained more weight than XO+PAR mice. B, Similarly in the first 3 nights during the active period, the amount of food eaten correlated with the number of sex chromosomes (1-way ANOVA, 1 vs 2 vs 3 non-PAR regions of sex chromosomes, F(2,48) = 14.2, P < .00002). XXY mice ate more than XO+PAR mice. C, The amount of food consumed during the first 3 days did not differ among groups. D and E,

and

body temperature at the end of the 16-week HFD period was higher in mice with fewer sex chromosomes (1-way ANOVA, 1 vs 2 vs 3 sex chromosomes, F(2,48) = 11.1, P < .002). In the

, pairwise comparisons showed that XXY and XY mice had lower body temperature than XO+PAR mice (F(1,14) = 21, P = .0004, XXY vs XO+PAR; F(1,20) = 7.1, P = .015, XY vs XO+PAR). F, Blood glucose levels after injection of glucose. G, Area under the curve in F. Glucose clearance was slightly more efficient for mice having 1 X chromosome than the other 3 groups (1-way ANOVA on AUC, comparing mice with 1 vs 2 vs 3 non-PAR regions of sex chromosomes [F(2,66) = 4.11, P = .02]). *P < .05, ***P < .001, †P < .0001, ‡P < .00001.