Treatment of carbapenem-resistant Klebsiella pneumoniae: the state of the art - PubMed (original) (raw)
Review
Treatment of carbapenem-resistant Klebsiella pneumoniae: the state of the art
Nicola Petrosillo et al. Expert Rev Anti Infect Ther. 2013 Feb.
Abstract
The increasing incidence of carbapenem-resistant Klebsiella pneumoniae (CR-KP) fundamentally alters the management of patients at risk to be colonized or infected by such microorganisms. Owing to the limitation in efficacy and potential for toxicity of the alternative agents, many experts recommend using combination therapy instead of monotherapy in CR-KP-infected patients. However, in the absence of well-designed comparative studies, the best combination for each infection type, the continued role for carbapenems in combination therapy and when combination therapy should be started remain open questions. Herein, the authors revise current microbiological and clinical evidences supporting combination therapy for CR-KP infections to address some of these issues.
Similar articles
- Critical issues for Klebsiella pneumoniae KPC-carbapenemase producing K. pneumoniae infections: a critical agenda.
De Rosa FG, Corcione S, Cavallo R, Di Perri G, Bassetti M. De Rosa FG, et al. Future Microbiol. 2015;10(2):283-94. doi: 10.2217/fmb.14.121. Future Microbiol. 2015. PMID: 25689539 Review. - In vitro activity of tigecycline in combination with rifampin, doripenem or ceftazidime against carbapenem-resistant Klebsiella pneumoniae bloodstream isolates.
Zhang Y, Li P, Yin Y, Li F, Zhang Q. Zhang Y, et al. J Antibiot (Tokyo). 2017 Feb;70(2):193-195. doi: 10.1038/ja.2016.93. Epub 2016 Jul 27. J Antibiot (Tokyo). 2017. PMID: 27460764 No abstract available. - Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review.
Jacobs DM, Safir MC, Huang D, Minhaj F, Parker A, Rao GG. Jacobs DM, et al. Ann Clin Microbiol Antimicrob. 2017 Nov 25;16(1):76. doi: 10.1186/s12941-017-0249-2. Ann Clin Microbiol Antimicrob. 2017. PMID: 29178957 Free PMC article. Review. - Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin.
Neonakis IK, Samonis G, Messaritakis H, Baritaki S, Georgiladakis A, Maraki S, Spandidos DA. Neonakis IK, et al. Chemotherapy. 2010;56(6):448-52. doi: 10.1159/000320943. Epub 2010 Nov 18. Chemotherapy. 2010. PMID: 21088396 - Effect of combination therapy containing a high-dose carbapenem on mortality in patients with carbapenem-resistant Klebsiella pneumoniae bloodstream infection.
Giannella M, Trecarichi EM, Giacobbe DR, De Rosa FG, Bassetti M, Bartoloni A, Bartoletti M, Losito AR, Del Bono V, Corcione S, Tedeschi S, Raffaelli F, Saffioti C, Spanu T, Rossolini GM, Marchese A, Ambretti S, Cauda R, Viscoli C, Lewis RE, Viale P, Tumbarello M; Italian Study Group on Resistant Infections of the Società Italiana Terapia Antinfettiva (ISGRI-SITA). Giannella M, et al. Int J Antimicrob Agents. 2018 Feb;51(2):244-248. doi: 10.1016/j.ijantimicag.2017.08.019. Epub 2017 Aug 24. Int J Antimicrob Agents. 2018. PMID: 28842283
Cited by
- Urinary Tract Infections with Carbapenem-Resistant Klebsiella pneumoniae in a Urology Clinic-A Case-Control Study.
Radu VD, Costache RC, Onofrei P, Miron A, Bandac CA, Arseni D, Mironescu M, Miftode RS, Boiculese LV, Miftode IL. Radu VD, et al. Antibiotics (Basel). 2024 Jun 24;13(7):583. doi: 10.3390/antibiotics13070583. Antibiotics (Basel). 2024. PMID: 39061265 Free PMC article. - In Vitro antibiotic combinations of Colistin, Meropenem, Amikacin, and Amoxicillin/clavulanate against multidrug-resistant Klebsiella pneumonia isolated from patients with ventilator-associated pneumonia.
Bayatinejad G, Salehi M, Beigverdi R, Halimi S, Emaneini M, Jabalameli F. Bayatinejad G, et al. BMC Microbiol. 2023 Oct 20;23(1):298. doi: 10.1186/s12866-023-03039-w. BMC Microbiol. 2023. PMID: 37864176 Free PMC article. - Antibiotic Therapy Strategies for Treating Gram-Negative Severe Infections in the Critically Ill: A Narrative Review.
Corona A, De Santis V, Agarossi A, Prete A, Cattaneo D, Tomasini G, Bonetti G, Patroni A, Latronico N. Corona A, et al. Antibiotics (Basel). 2023 Jul 31;12(8):1262. doi: 10.3390/antibiotics12081262. Antibiotics (Basel). 2023. PMID: 37627683 Free PMC article. Review. - Analysis of Antimicrobial Susceptibility in Bacterial Pathogens Associated with Urinary Tract Infections from Beijing Teaching Hospital in China, 2009-2017.
Xie Z, Jian J, Chen L. Xie Z, et al. Can J Infect Dis Med Microbiol. 2023 Jul 24;2023:4360342. doi: 10.1155/2023/4360342. eCollection 2023. Can J Infect Dis Med Microbiol. 2023. PMID: 37529141 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical