The origins and drivers of insulin resistance - PubMed (original) (raw)
. 2013 Feb 14;152(4):673-84.
doi: 10.1016/j.cell.2013.01.041.
Affiliations
- PMID: 23415219
- DOI: 10.1016/j.cell.2013.01.041
Free article
The origins and drivers of insulin resistance
Andrew M F Johnson et al. Cell. 2013.
Free article
Abstract
Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
- [Microbiota and obesity].
Karney A. Karney A. Dev Period Med. 2017;21(3):203-207. doi: 10.34763/devperiodmed.20172103.203207. Dev Period Med. 2017. PMID: 29077559 Free PMC article. Polish. - [The role of gut microbiota in the pathogenesis of obesity and diabetes].
Stachowicz N, Kiersztan A. Stachowicz N, et al. Postepy Hig Med Dosw (Online). 2013 Apr 15;67:288-303. doi: 10.5604/17322693.1044746. Postepy Hig Med Dosw (Online). 2013. PMID: 23619228 Review. Polish. - Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
Diamant M, Blaak EE, de Vos WM. Diamant M, et al. Obes Rev. 2011 Apr;12(4):272-81. doi: 10.1111/j.1467-789X.2010.00797.x. Epub 2010 Aug 26. Obes Rev. 2011. PMID: 20804522 Review. - Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes.
Dahik VD, Frisdal E, Le Goff W. Dahik VD, et al. Int J Mol Sci. 2020 Jul 31;21(15):5505. doi: 10.3390/ijms21155505. Int J Mol Sci. 2020. PMID: 32752107 Free PMC article. Review. - Microbial modulation of insulin sensitivity.
Khan MT, Nieuwdorp M, Bäckhed F. Khan MT, et al. Cell Metab. 2014 Nov 4;20(5):753-760. doi: 10.1016/j.cmet.2014.07.006. Cell Metab. 2014. PMID: 25176147
Cited by
- Aerobic Exercise Prevents High-Fat-Diet-Induced Adipose Tissue Dysfunction in Male Mice.
Guo Q, Li N, Shi H, Gan Y, Wang W, Jia J, Zhou Y. Guo Q, et al. Nutrients. 2024 Oct 11;16(20):3451. doi: 10.3390/nu16203451. Nutrients. 2024. PMID: 39458447 Free PMC article. - MicroRNA regulatory networks in human adipose tissue and obesity.
Arner P, Kulyté A. Arner P, et al. Nat Rev Endocrinol. 2015 May;11(5):276-88. doi: 10.1038/nrendo.2015.25. Epub 2015 Mar 3. Nat Rev Endocrinol. 2015. PMID: 25732520 Review. - Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Lee HY, Kim J, Quan W, Lee JC, Kim MS, Kim SH, Bae JW, Hur KY, Lee MS. Lee HY, et al. Autophagy. 2016 Aug 2;12(8):1390-403. doi: 10.1080/15548627.2016.1184799. Epub 2016 Jun 23. Autophagy. 2016. PMID: 27337687 Free PMC article. - Epigenetics of Hepatic Insulin Resistance.
Maude H, Sanchez-Cabanillas C, Cebola I. Maude H, et al. Front Endocrinol (Lausanne). 2021 May 11;12:681356. doi: 10.3389/fendo.2021.681356. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34046015 Free PMC article. Review. - Adipose tissue, immune aging, and cellular senescence.
Frasca D, Blomberg BB. Frasca D, et al. Semin Immunopathol. 2020 Oct;42(5):573-587. doi: 10.1007/s00281-020-00812-1. Epub 2020 Aug 12. Semin Immunopathol. 2020. PMID: 32785750 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
- DK033651/DK/NIDDK NIH HHS/United States
- DK-09062/DK/NIDDK NIH HHS/United States
- P50 HD012303/HD/NICHD NIH HHS/United States
- U54 HD012303/HD/NICHD NIH HHS/United States
- DK074868/DK/NIDDK NIH HHS/United States
- DK-063491/DK/NIDDK NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical