VEGF-B expression in colorectal carcinomas and its relevance for tumor progression - PubMed (original) (raw)
doi: 10.14670/HH-28.647. Epub 2013 Feb 18.
Affiliations
- PMID: 23417498
- DOI: 10.14670/HH-28.647
VEGF-B expression in colorectal carcinomas and its relevance for tumor progression
Caren Jayasinghe et al. Histol Histopathol. 2013 May.
Abstract
The biological behavior of VEGF-B, a ligand of the receptor VEGFR-1, is still enigmatic. Despite its high sequence homology to the better known angiogenetic factor VEGF-A, the function of VEGF-B has remained elusive. Especially, its role in tumor biology has thus far not been defined. In the present study we address the question of whether VEGF-B could play a role in the metastatic process of colorectal carcinomas (CRC). Using immunohistochemistry we investigated its expression in the tumor tissue of 91 non-metastatic, lymphogenous-metastatic and haematogenous-metastastic CRC. Independently of metastatic status, VEGF-B was expressed in endothelial as well as in tumor cells. 81% of the CRC showed a positive, partly focal, partly disseminated endothelial expression in intratumoral vessels and the vascular fraction throughout the invasive tumor margin. Almost all of the VEGF-B positive vessels were of blood vascular origin. Many of these were thick-walled blood vessels with atherosclerotic changes characterizing preexistent but not angiogenetic vasculature. Thus it appears that VEGF-B might be an important ligand to ensure the blood supply for tumor survival. 46% of the CRC presented an additional tumoral VEGF-B expression which significantly correlated with haematogenous metastasis (p=0.006). These morphological results provide evidence for a probable pathobiological significance of VEGF-B in the tumor progression of CRC, especially in the case of haematogenous metastasis. It appears that VEGF-B might be an important ligand in the signalling between the tumor and preexisting blood vessels to ensure a functional blood supply for tumor survival.
Similar articles
- The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression.
Hanrahan V, Currie MJ, Gunningham SP, Morrin HR, Scott PA, Robinson BA, Fox SB. Hanrahan V, et al. J Pathol. 2003 Jun;200(2):183-94. doi: 10.1002/path.1339. J Pathol. 2003. PMID: 12754739 - Vascular endothelial growth factors C and D represent novel prognostic markers in colorectal carcinoma using quantitative image analysis.
Hu WG, Li JW, Feng B, Beveridge M, Yue F, Lu AG, Ma JJ, Wang ML, Guo Y, Jin XL, Zheng MH. Hu WG, et al. Eur Surg Res. 2007;39(4):229-38. doi: 10.1159/000101855. Epub 2007 Apr 19. Eur Surg Res. 2007. PMID: 17446709 - Endothelial VEGFR-3 expression in colorectal carcinomas is associated with hematogenous metastasis.
Jayasinghe C, Simiantonaki N, Michel-Schmidt R, Kirkpatrick CJ. Jayasinghe C, et al. Oncol Rep. 2009 Nov;22(5):1093-100. doi: 10.3892/or_00000541. Oncol Rep. 2009. PMID: 19787226 - Biomarkers Discovery for Colorectal Cancer: A Review on Tumor Endothelial Markers as Perspective Candidates.
Pietrzyk Ł. Pietrzyk Ł. Dis Markers. 2016;2016:4912405. doi: 10.1155/2016/4912405. Epub 2016 Nov 14. Dis Markers. 2016. PMID: 27965519 Free PMC article. Review. - Complicated life, complicated VEGF-B.
Li X, Kumar A, Zhang F, Lee C, Tang Z. Li X, et al. Trends Mol Med. 2012 Feb;18(2):119-27. doi: 10.1016/j.molmed.2011.11.006. Epub 2011 Dec 15. Trends Mol Med. 2012. PMID: 22178229 Review.
Cited by
- Examining SNP-SNP interactions and risk of clinical outcomes in colorectal cancer using multifactor dimensionality reduction based methods.
Curtis A, Yu Y, Carey M, Parfrey P, Yilmaz YE, Savas S. Curtis A, et al. Front Genet. 2022 Aug 3;13:902217. doi: 10.3389/fgene.2022.902217. eCollection 2022. Front Genet. 2022. PMID: 35991579 Free PMC article. - Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer.
Chen C, Ge X, Zhao Y, Wang D, Ling L, Zheng S, Ding K, Wang J, Sun L. Chen C, et al. Front Oncol. 2020 Dec 10;10:605349. doi: 10.3389/fonc.2020.605349. eCollection 2020. Front Oncol. 2020. PMID: 33363035 Free PMC article. Review. - Role of VEGFs/VEGFR-1 Signaling and its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models.
Ceci C, Atzori MG, Lacal PM, Graziani G. Ceci C, et al. Int J Mol Sci. 2020 Feb 18;21(4):1388. doi: 10.3390/ijms21041388. Int J Mol Sci. 2020. PMID: 32085654 Free PMC article. Review. - Vascular Endothelial Growth Factor B and Its Signaling.
Lal N, Puri K, Rodrigues B. Lal N, et al. Front Cardiovasc Med. 2018 Apr 20;5:39. doi: 10.3389/fcvm.2018.00039. eCollection 2018. Front Cardiovasc Med. 2018. PMID: 29732375 Free PMC article. - Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection.
Stremitzer S, Zhang W, Yang D, Ning Y, Sunakawa Y, Matsusaka S, Parekh A, Okazaki S, Hanna D, Astrow SH, Moran M, Hernandez J, Stephens C, Scherer SJ, Stift J, Wrba F, Gruenberger T, Lenz HJ. Stremitzer S, et al. Mol Cancer Ther. 2016 Nov;15(11):2814-2821. doi: 10.1158/1535-7163.MCT-16-0275. Epub 2016 Aug 17. Mol Cancer Ther. 2016. PMID: 27535973 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical