Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease - PubMed (original) (raw)

doi: 10.1002/ana.23817. Epub 2013 Feb 19.

Affiliations

• PMID: 23424051
• DOI: 10.1002/ana.23817

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Scott Ayton et al. Ann Neurol. 2013 Apr.

Abstract

Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia. We found a ∼80% loss of ceruloplasmin ferroxidase activity in the substantia nigra of idiopathic Parkinson disease (PD) cases, which could contribute to the pro-oxidant iron accumulation that characterizes the pathology. Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation. Additionally, peripheral infusion of ceruloplasmin attenuated neurodegeneration and nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model for PD. These findings show, in principle, that intravenous ceruloplasmin may have therapeutic potential in PD.

Copyright © 2013 American Neurological Association.

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