Novel link between inflammation, endothelial dysfunction, and muscle insulin resistance - PubMed (original) (raw)

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Franck Mauvais-Jarvis. Diabetes. 2013 Mar.

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FIG. 1.

FIG. 1.

Role of CRP in skeletal muscle insulin resistance. In the normal state, insulin signaling in endothelial cells stimulates the phosphorylation and activation of the eNOS on S1176 residue to increase muscle blood flow, thereby promoting muscle glucose delivery and insulin sensitivity. During inflammation, CRP activation of FcγRIIB in muscle endothelial cells causes eNOS-S1176 dephosphorylation leading to impaired insulin endothelial action in skeletal muscle, impaired muscle glucose delivery, and insulin resistance.

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References

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