Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels - PubMed (original) (raw)

Randomized Controlled Trial

. 2013 Aug;274(2):163-75.

doi: 10.1111/joim.12062. Epub 2013 Mar 29.

A McTiernan, C M Alfano, M H Wener, K L Campbell, C Duggan, K E Foster-Schubert, A Kong, A T Toriola, J D Potter, C Mason, L Xiao, G L Blackburn, C Bain, C M Ulrich

Affiliations

Randomized Controlled Trial

Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels

C Abbenhardt et al. J Intern Med. 2013 Aug.

Erratum in

Abstract

Background: Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated the effects of 12-month reduced calorie, weight loss and exercise interventions on adiponectin and leptin concentrations.

Methods: Overweight/obese postmenopausal women (n = 439) were randomized as follows: (i) a reduced calorie, weight-loss diet (diet; N = 118), (ii) moderate-to-vigorous intensity aerobic exercise (exercise; N = 117), (iii) a combination of a reduced calorie, weight-loss diet and moderate-to-vigorous intensity aerobic exercise (diet + exercise; N = 117), and (iv) control (N = 87). The reduced calorie diet had a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous aerobic activity 5 days per week. Adiponectin and leptin levels were measured at baseline and after 12 months of intervention using a radioimmunoassay.

Results: Adiponectin increased by 9.5% in the diet group and 6.6% in the diet + exercise group (both P ≤ 0.0001 vs. control). Compared with controls, leptin decreased with all interventions (diet + exercise, -40.1%, P < 0.0001; diet, -27.1%, P < 0.0001; exercise, -12.7%, P = 0.005). The results were not influenced by the baseline body mass index (BMI). The degree of weight loss was inversely associated with concentrations of adiponectin (diet, P-trend = 0.0002; diet + exercise, P-trend = 0.0005) and directly associated with leptin (diet, P-trend < 0.0001; diet + exercise, P-trend < 0.0001).

Conclusion: Weight loss through diet or diet + exercise increased adiponectin concentrations. Leptin concentrations decreased in all of the intervention groups, but the greatest reduction occurred with diet + exercise. Weight loss and exercise exerted some beneficial effects on chronic diseases via effects on adiponectin and leptin.

Keywords: adiponectin; diet and exercise intervention; leptin; randomized controlled trial.

© 2013 The Association for the Publication of the Journal of Internal Medicine.

PubMed Disclaimer

Figures

Figure 1

Figure 1

CONSORT diagram of the Nutrition and Exercise for Women (NEW) trial

Figure 2

Figure 2

Effect of individual and combined dietry weight loss and excercise interventions on adiponectin and leptin, startified by change in % body fat (geometric mean)

Comment in

Similar articles

Cited by

References

    1. Ford ES, Bergmann MM, Kroger J, Schienkiewitz A, Weikert C, Boeing H. Healthy living is the best revenge: findings from the European Prospective Investigation Into Cancer and Nutrition-Potsdam study. Archives of internal medicine. 2009;169:1355–62. - PubMed
    1. Poirier P, Eckel RH. Obesity and cardiovascular disease. Current atherosclerosis reports. 2002;4:448–53. - PubMed
    1. Whitlock G, Lewington S, Sherliker P, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083–96. - PMC - PubMed
    1. Lorenzo C, Serrano-Rios M, Martinez-Larrad MT, et al. Which obesity index best explains prevalence differences in type 2 diabetes mellitus? Obesity (Silver Spring) 2007;15:1294–301. - PubMed
    1. WCRF . World Cancer Research Fund: Food Nutrition, Physical Activity, and the Prevention of Cancer: A global Perspective. AICR; Washington, D.C.: 2007.

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources