Primary structure and biological activity of a novel human neurotrophic factor - PubMed (original) (raw)
Primary structure and biological activity of a novel human neurotrophic factor
A Rosenthal et al. Neuron. 1990 May.
Abstract
During development, each tissue receives and maintains a number of specific neuronal projections that are adequate to sustain its function. The mechanism by which this intricate process occurs is not well understood, but it has been proposed that diffusible neurotrophic factors derived from the target tissue may be involved. Here we describe the identification of a novel human protein that is important for the growth, differentiation, and survival of primary sympathetic and placode-derived sensory neurons. This polypeptide, designated neuronotrophin-3, has a broad tissue distribution and is structurally related to both nerve growth factor and brain-derived neurotrophic factor. Its unique range of trophic and differentiation-inducing activities suggests that it is likely to play a wide role in defining the fate and function of nerve cells during development.
Similar articles
- Brain-derived neurotrophic factor is more highly conserved in structure and function than nerve growth factor during vertebrate evolution.
Götz R, Raulf F, Schartl M. Götz R, et al. J Neurochem. 1992 Aug;59(2):432-42. doi: 10.1111/j.1471-4159.1992.tb09389.x. J Neurochem. 1992. PMID: 1629719 - Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
Maisonpierre PC, Belluscio L, Squinto S, Ip NY, Furth ME, Lindsay RM, Yancopoulos GD. Maisonpierre PC, et al. Science. 1990 Mar 23;247(4949 Pt 1):1446-51. doi: 10.1126/science.247.4949.1446. Science. 1990. PMID: 2321006 - Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.
Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV, Rosenthal A. Berkemeier LR, et al. Neuron. 1991 Nov;7(5):857-66. doi: 10.1016/0896-6273(91)90287-a. Neuron. 1991. PMID: 1742028 - Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.
Lindsay RM. Lindsay RM. Philos Trans R Soc Lond B Biol Sci. 1996 Mar 29;351(1338):365-73. doi: 10.1098/rstb.1996.0030. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8730773 Review. - Neurotrophic factors in regeneration.
Richardson PM. Richardson PM. Curr Opin Neurobiol. 1991 Oct;1(3):401-6. doi: 10.1016/0959-4388(91)90061-b. Curr Opin Neurobiol. 1991. PMID: 1688352 Review.
Cited by
- Neurotrophins and Their Receptors: BDNF's Role in GABAergic Neurodevelopment and Disease.
Hernández-Del Caño C, Varela-Andrés N, Cebrián-León A, Deogracias R. Hernández-Del Caño C, et al. Int J Mol Sci. 2024 Jul 30;25(15):8312. doi: 10.3390/ijms25158312. Int J Mol Sci. 2024. PMID: 39125882 Free PMC article. Review. - Detection and Quantification of Neurotrophin-3 (NT-3) and Nerve Growth Factor (NGF) Levels in Early Second Trimester Amniotic Fluid: Investigation into a Possible Correlation with Abnormal Fetal Growth Velocity Patterns.
Machairiotis N, Vrachnis D, Antonakopoulos N, Loukas N, Fotiou A, Pergialiotis V, Stavros S, Mantzou A, Maroudias G, Iavazzo C, Kanaka-Gantenbein C, Drakakis P, Troupis T, Vlasis K, Vrachnis N. Machairiotis N, et al. J Clin Med. 2023 Jun 19;12(12):4131. doi: 10.3390/jcm12124131. J Clin Med. 2023. PMID: 37373824 Free PMC article. - Therapeutic Strategies Targeting Respiratory Recovery after Spinal Cord Injury: From Preclinical Development to Clinical Translation.
Michel-Flutot P, Lane MA, Lepore AC, Vinit S. Michel-Flutot P, et al. Cells. 2023 May 31;12(11):1519. doi: 10.3390/cells12111519. Cells. 2023. PMID: 37296640 Free PMC article. Review. - Neurotrophic factors in the porcine ovary: Their effects on follicular growth, oocyte maturation, and developmental competence.
Kim M, Hyun SH. Kim M, et al. Front Vet Sci. 2022 Aug 10;9:931402. doi: 10.3389/fvets.2022.931402. eCollection 2022. Front Vet Sci. 2022. PMID: 36032306 Free PMC article. Review. - The Roles of Neurotrophins in Traumatic Brain Injury.
Lin PH, Kuo LT, Luh HT. Lin PH, et al. Life (Basel). 2021 Dec 24;12(1):26. doi: 10.3390/life12010026. Life (Basel). 2021. PMID: 35054419 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases