Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene - PubMed (original) (raw)
. 2013 Apr 25;121(17):3428-30.
doi: 10.1182/blood-2012-06-437210. Epub 2013 Mar 1.
Eevi Kaasinen, Marja-Liisa Karjalainen-Lindsberg, Kari Vesanen, Mervi Aavikko, Riku Katainen, Minna Taskinen, Soili Kytölä, Sirpa Leppä, Marja Hietala, Pia Vahteristo, Lauri A Aaltonen
Affiliations
- PMID: 23457195
- DOI: 10.1182/blood-2012-06-437210
Free article
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene
Silva Saarinen et al. Blood. 2013.
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Abstract
Primary mediastinal large B-cell lymphoma (PMBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) accounting for 2% to 4% of all non-Hodgkin lymphomas. We report a family of 3 siblings with PMBCL and their cousin with extranodal DLBCL. The histopathological characteristics of lymphomas of all 4 patients are similar, implying post-germinal center differentiation and growth deregulation by other mechanisms than BCL2-mediated inhibition of apoptosis and suggesting a shared biological background. We aimed to identify the genetic defect underlying lymphoma susceptibility in this family using exome sequencing and linkage analysis. The only variant segregating in all 4 patients and not reported in genetic databases was 5533C>A (His1845Asn) in the MLL gene. To our knowledge, this is the first time when familial clustering of PMBCL is reported. Although we propose MLL as a candidate predisposition gene for this condition, this finding needs to be validated in additional cases.
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