Virion assembly and release - PubMed (original) (raw)

Review

Virion assembly and release

Brett D Lindenbach. Curr Top Microbiol Immunol. 2013.

Abstract

Hepatitis C Virus (HCV) particles exhibit several unusual properties that are not found in other enveloped RNA viruses, most notably their low buoyant density and interaction with serum lipoproteins. With the advent of systems to grow HCV in cell culture, the molecular basis of HCV particle assembly and release can now be addressed. The process of virus assembly involves protein-protein interactions between viral structural and nonstructural proteins and the coordinated action of host factors. This chapter reviews our current understanding of these interactions and factors.

PubMed Disclaimer

Figures

Fig. 1

HCV particles interact with low-density lipoproteins. (a) A model of an HCV particle, based on the structure of flaviviruses. The surface of the enveloped virus particle is decorated with the viral E1–E2 glycoproteins. Within the virus particle is a nucelocapsid formed by core protein and the viral RNA genome. (b) A comparison of enveloped RNA virus buoyant densities. Range bars indicate the buoyant density of viruses within each taxonomic group (data obtained from the International Committee on Taxonomy of Viruses website). The buoyant density of serum lipoproteins are indicated at the bottom for comparison. (c–g). Illustrations show putative interactions between an HCV particles and VLDL particles. See text for further description.

Fig. 2

Model of HCV particle assembly. RNA is packaged See text for further description.

Cited by

Integrated stress response in hepatitis C promotes Nrf2-related chaperone-mediated autophagy: A novel mechanism for host-microbe survival and HCC development in liver cirrhosis.
Dash S, Aydin Y, Wu T. Dash S, et al. Semin Cell Dev Biol. 2020 May;101:20-35. doi: 10.1016/j.semcdb.2019.07.015. Epub 2019 Aug 8. Semin Cell Dev Biol. 2020. PMID: 31386899 Free PMC article. Review.
Hepatitis C virus genotypes 1-3 infections regulate lipogenic signaling and suppress cholesterol biosynthesis in hepatocytes.
Hsu CS, Liu WL, Li Q, Lowey B, Hertz L, Chao YC, Liang TJ, Chen DS, Kao JH. Hsu CS, et al. J Formos Med Assoc. 2020 Sep;119(9):1382-1395. doi: 10.1016/j.jfma.2020.03.018. Epub 2020 Apr 10. J Formos Med Assoc. 2020. PMID: 32284164 Free PMC article.
The ins and outs of viral infection: keystone meeting review.
Bird SW, Kirkegaard K, Agbandje-McKenna M, Freed EO. Bird SW, et al. Viruses. 2014 Sep 25;6(9):3652-62. doi: 10.3390/v6093652. Viruses. 2014. PMID: 25256395 Free PMC article.
Cyclophilins and Their Roles in Hepatitis C Virus and Flavivirus Infections: Perspectives for Novel Antiviral Approaches.
Gallardo-Flores CE, Colpitts CC. Gallardo-Flores CE, et al. Pathogens. 2021 Jul 17;10(7):902. doi: 10.3390/pathogens10070902. Pathogens. 2021. PMID: 34358052 Free PMC article. Review.

References

1. Aizaki H, Morikawa K, Fukasawa M, et al. Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection. J Virol. 2008;82:5715–5724. 10.1128/JVI.02530-07. - PMC - PubMed
1. Albecka A, Montserret R, Krey T, et al. Identification of new functional regions in hepatitis C virus envelope glycoprotein E2. J Virol. 2011;85:1777–1792. 10.1128/JVI.02170-10. - PMC - PubMed
1. André P, Komurian-Pradel F, Deforges S, et al. Characterization of low-and very-low-density hepatitis C virus RNA-containing particles. J Virol. 2002;76:6919–6928. - PMC - PubMed
1. Appel N, Zayas M, Miller S, et al. Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog. 2008;4:e1000035. - PMC - PubMed
1. Ariumi Y, Kuroki M, Maki M, Ikeda M, Dansako H, Wakita T, Kato N. The ESCRT system is required for hepatitis C virus production. PLoS One. 2011;6:e14517. - PMC - PubMed

Virion assembly and release - PubMed (original) (raw)