Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation - PubMed (original) (raw)
Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation
S Araki et al. Biochem Biophys Res Commun. 1990.
Erratum in
- Biochem Biophys Res Commun 1990 Jun 29;169(3):1248
Abstract
Survival and proliferation of many types of vascular endothelial cells are influenced by fibroblast growth factor (FGF)1. Removal of FGF from the medium of human umbilical vein endothelial cells (HUVEC) in culture resulted in death of the cells. Here we show that the death caused by deprivation of FGF is active death or apoptosis, and the process of apoptosis can be inhibited by cycloheximide, an inhibitor of protein synthesis. The present study shows apoptosis occurs in endothelial cells in culture. The process of active death of vascular endothelial cells is inhibited by growth factor. This mechanism may be important for the regulation of vascular organization through the degeneration of vessels.
Similar articles
- Extracellular matrix of retinal pigment epithelium regulates choriocapillaris endothelial survival in vitro.
Liu X, Ye X, Yanoff M, Li W. Liu X, et al. Exp Eye Res. 1997 Jul;65(1):117-26. doi: 10.1006/exer.1997.0317. Exp Eye Res. 1997. PMID: 9237872 - Autocrine FGF-2 is responsible for the cell density-dependent susceptibility to apoptosis of HUVEC : A role of a calpain inhibitor-sensitive mechanism.
Kinoshita M, Shimokado K. Kinoshita M, et al. Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2323-9. doi: 10.1161/01.atv.19.10.2323. Arterioscler Thromb Vasc Biol. 1999. PMID: 10521360 - Regulatory effects of soluble growth factors on choriocapillaris endothelial growth and survival.
Liu X, Ye X, Yanoff M, Li W. Liu X, et al. Ophthalmic Res. 1998;30(5):302-13. doi: 10.1159/000055489. Ophthalmic Res. 1998. PMID: 9704334 - Expression of fibroblast growth factor-5 by bovine choroidal endothelial cells in vitro.
Keithahn MA, Aotaki-Keen AE, Schneeberger SA, Hjelmeland LM, Morse LS. Keithahn MA, et al. Invest Ophthalmol Vis Sci. 1997 Sep;38(10):2073-80. Invest Ophthalmol Vis Sci. 1997. PMID: 9331271 - Expression and control of vascular endothelial cells: proliferation and differentiation by fibroblast growth factors.
Gospodarowicz D. Gospodarowicz D. J Invest Dermatol. 1989 Aug;93(2 Suppl):39S-47S. doi: 10.1111/1523-1747.ep12580907. J Invest Dermatol. 1989. PMID: 2474036 Review.
Cited by
- The duality of amyloid-β: its role in normal and Alzheimer's disease states.
Azargoonjahromi A. Azargoonjahromi A. Mol Brain. 2024 Jul 17;17(1):44. doi: 10.1186/s13041-024-01118-1. Mol Brain. 2024. PMID: 39020435 Free PMC article. Review. - Release of cell surface proteoglycans from differentiating colon cells proceeds by cleavage of lipophilic anchor peptides.
McBain JA, Mueller GC. McBain JA, et al. Biochem J. 1992 Oct 1;287 ( Pt 1)(Pt 1):131-40. doi: 10.1042/bj2870131. Biochem J. 1992. PMID: 1417765 Free PMC article. - Novel Role of Heterogeneous Nuclear Ribonucleoprotein E1 in Regulation of Apoptosis and Autophagy by a Triazole Derivative in Vascular Endothelial Cells.
Meng N, Gong Y, Mu X, Wang YH, Su L, Jiang CS, Zhang H. Meng N, et al. Int J Biol Sci. 2019 May 12;15(6):1299-1309. doi: 10.7150/ijbs.32677. eCollection 2019. Int J Biol Sci. 2019. PMID: 31223288 Free PMC article. - Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms.
Karsan A, Yee E, Poirier GG, Zhou P, Craig R, Harlan JM. Karsan A, et al. Am J Pathol. 1997 Dec;151(6):1775-84. Am J Pathol. 1997. PMID: 9403728 Free PMC article. - p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.
Merlo GR, Basolo F, Fiore L, Duboc L, Hynes NE. Merlo GR, et al. J Cell Biol. 1995 Mar;128(6):1185-96. doi: 10.1083/jcb.128.6.1185. J Cell Biol. 1995. PMID: 7896881 Free PMC article.