Neuroimaging for the prediction of response to medical and surgical treatment in epilepsy - PubMed (original) (raw)
Neuroimaging for the prediction of response to medical and surgical treatment in epilepsy
Clarissa Lin Yasuda et al. Expert Opin Med Diagn. 2012 Jul.
Abstract
Introduction: Approximately 30% of patients with epilepsy do not respond to adequate medication and are candidates for surgical treatment. Outcome predictors can improve the selection of more suitable treatment options for each patient. Therefore, the authors aimed to review the role of neuroimaging studies in predicting outcomes for both clinical and surgical treatment of epilepsy.
Areas covered: This review analyzes studies that investigated different neuroimaging techniques as predictors of clinical and surgical treatment outcome in epilepsy. Studies involving both structural (i.e., T1-weighted images and diffusion tensor images) and functional MRI (fMRI) were identified, as well as other modalities such as spectroscopy, PET, SPECT and MEG. The authors also evaluated the importance of fMRI in predicting memory outcome after surgical resections in temporal lobe epilepsy.
Expert opinion: The identification of reliable biomarkers to predict response to medical and surgical treatments are much needed in order to provide more adequate patient counseling about prognosis and treatment options individually. Different neuroimaging techniques may provide combined measurements that potentially may become these biomarkers in the near future.
Similar articles
- Epilepsy surgery.
Wieser HG. Wieser HG. Baillieres Clin Neurol. 1996 Dec;5(4):849-75. Baillieres Clin Neurol. 1996. PMID: 9068885 Review. - Neuroimaging of focal cortical dysplasia.
Widdess-Walsh P, Diehl B, Najm I. Widdess-Walsh P, et al. J Neuroimaging. 2006 Jul;16(3):185-96. doi: 10.1111/j.1552-6569.2006.00025.x. J Neuroimaging. 2006. PMID: 16808819 Review. - Neuroimaging of epilepsy.
Maehara T. Maehara T. Neuropathology. 2007 Dec;27(6):585-93. doi: 10.1111/j.1440-1789.2007.00793.x. Neuropathology. 2007. PMID: 18021381 Review. - [Indications and outcomes of epilepsy surgery in children].
Sell-Marucco E. Sell-Marucco E. Rev Neurol. 2006 Apr 10;42 Suppl 3:S61-6. Rev Neurol. 2006. PMID: 16642454 Review. Spanish. - Multimodal neuroimaging: potential biomarkers for response to antiepileptic drugs?
Coan AC, Cendes F. Coan AC, et al. Epilepsia. 2013 May;54 Suppl 2:67-70. doi: 10.1111/epi.12188. Epilepsia. 2013. PMID: 23646975 Review.
Cited by
- Not all that glitters is gold: A guide to surgical trials in epilepsy.
Jehi L, Jetté N. Jehi L, et al. Epilepsia Open. 2016 Jul 27;1(1-2):22-36. doi: 10.1002/epi4.4. eCollection 2016 Sep. Epilepsia Open. 2016. PMID: 29588926 Free PMC article. Review. - Neuroimaging in investigation of patients with epilepsy.
Cendes F. Cendes F. Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):623-42. doi: 10.1212/01.CON.0000431379.29065.d3. Continuum (Minneap Minn). 2013. PMID: 23739101 Free PMC article. Review. - Neuroimaging of epilepsy.
Cendes F, Theodore WH, Brinkmann BH, Sulc V, Cascino GD. Cendes F, et al. Handb Clin Neurol. 2016;136:985-1014. doi: 10.1016/B978-0-444-53486-6.00051-X. Handb Clin Neurol. 2016. PMID: 27430454 Free PMC article. Review. - More Severe Extratemporal Damages in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis Than That With Other Lesions: A Multimodality MRI Study.
Wei W, Zhang Z, Xu Q, Yang F, Sun K, Lu G. Wei W, et al. Medicine (Baltimore). 2016 Mar;95(10):e3020. doi: 10.1097/MD.0000000000003020. Medicine (Baltimore). 2016. PMID: 26962820 Free PMC article. - A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information.
Silva-Alves MS, Secolin R, Carvalho BS, Yasuda CL, Bilevicius E, Alvim MK, Santos RO, Maurer-Morelli CV, Cendes F, Lopes-Cendes I. Silva-Alves MS, et al. PLoS One. 2017 Jan 4;12(1):e0169214. doi: 10.1371/journal.pone.0169214. eCollection 2017. PLoS One. 2017. PMID: 28052106 Free PMC article.
LinkOut - more resources
Full Text Sources