Persistent effect of TGF-beta 1 on extracellular matrix gene expression in human dermal fibroblasts - PubMed (original) (raw)
Persistent effect of TGF-beta 1 on extracellular matrix gene expression in human dermal fibroblasts
O Ishikawa et al. Biochem Biophys Res Commun. 1990.
Abstract
TGF-beta, a potent inducer of the extracellular matrix, is also known to stimulate its own synthesis. In this report we have analyzed long term effects of TGF-beta 1 on its own expression and on the expression of extracellular matrix genes. We demonstrated that 24 hours of incubation of human dermal fibroblasts with TGF-beta 1 (1 ng/ml) under serum free conditions resulted in an elevated expression of TGF-beta 1, collagen alpha 2(I) and fibronectin mRNAs that persisted at least 96 hours after removal of TGF-beta 1. These data suggest the possibility of persistent in vivo activation of target cells following exposure to TGF-beta 1.
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