Flying tryps: survival and maturation of trypanosomes in tsetse flies - PubMed (original) (raw)
Review
Flying tryps: survival and maturation of trypanosomes in tsetse flies
Naomi A Dyer et al. Trends Parasitol. 2013 Apr.
Abstract
Survival in and colonization of the tsetse fly midgut are essential steps in the transmission of many species of African trypanosomes. In the fly, bloodstream trypanosomes transform into the procyclic stage within the gut lumen and later migrate to the ectoperitrophic space, where they multiply, establishing an infection. Progression of the parasite infection in the fly depends on factors inherent to the biology of trypanosomes, tsetse, and the bloodmeal. Flies usually eradicate infection early on with both pre-existing and inducible factors. Parasites, in contrast, respond to these stimuli by undergoing developmental changes, allowing a few to both survive and migrate within the tsetse. Here we discuss parasite and fly factors determining trypanosome colonization of the tsetse, focusing mainly on the midgut.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Similar articles
- Salivary gland infection: a sex-linked recessive character in tsetse?
Maudlin I, Welburn SC, Milligan P. Maudlin I, et al. Acta Trop. 1990 Oct;48(1):9-15. doi: 10.1016/0001-706x(90)90060-d. Acta Trop. 1990. PMID: 1980807 - Tsetse EP protein protects the fly midgut from trypanosome establishment.
Haines LR, Lehane SM, Pearson TW, Lehane MJ. Haines LR, et al. PLoS Pathog. 2010 Mar 5;6(3):e1000793. doi: 10.1371/journal.ppat.1000793. PLoS Pathog. 2010. PMID: 20221444 Free PMC article. - The effect of starvation on the susceptibility of teneral and non-teneral tsetse flies to trypanosome infection.
Kubi C, van den Abbeele J, DE Deken R, Marcotty T, Dorny P, van den Bossche P. Kubi C, et al. Med Vet Entomol. 2006 Dec;20(4):388-92. doi: 10.1111/j.1365-2915.2006.00644.x. Med Vet Entomol. 2006. PMID: 17199750 - Antigenic variation during the developmental cycle of Trypanosoma brucei.
Hajduk SL. Hajduk SL. J Protozool. 1984 Feb;31(1):41-7. J Protozool. 1984. PMID: 6204043 Review. - The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly.
Sharma R, Gluenz E, Peacock L, Gibson W, Gull K, Carrington M. Sharma R, et al. Trends Parasitol. 2009 Nov;25(11):517-24. doi: 10.1016/j.pt.2009.08.001. Epub 2009 Sep 9. Trends Parasitol. 2009. PMID: 19747880 Free PMC article. Review.
Cited by
- Skin deep.
Casas-Sánchez A, Acosta-Serrano Á. Casas-Sánchez A, et al. Elife. 2016 Oct 14;5:e21506. doi: 10.7554/eLife.21506. Elife. 2016. PMID: 27740910 Free PMC article. - Diversity of trypanosomes in humans and cattle in the HAT foci Mandoul and Maro, Southern Chad-A matter of concern for zoonotic potential?
Ibrahim MAM, Weber JS, Ngomtcho SCH, Signaboubo D, Berger P, Hassane HM, Kelm S. Ibrahim MAM, et al. PLoS Negl Trop Dis. 2021 Jun 9;15(6):e0009323. doi: 10.1371/journal.pntd.0009323. eCollection 2021 Jun. PLoS Negl Trop Dis. 2021. PMID: 34106914 Free PMC article. - Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.
Morrison LJ, Steketee PC, Tettey MD, Matthews KR. Morrison LJ, et al. Virulence. 2023 Dec;14(1):2150445. doi: 10.1080/21505594.2022.2150445. Virulence. 2023. PMID: 36419235 Free PMC article. Review. - The genome of sheep ked (Melophagus ovinus) reveals potential mechanisms underlying reproduction and narrower ecological niches.
Zhang Q, Zhou Q, Han S, Li Y, Wang Y, He H. Zhang Q, et al. BMC Genomics. 2023 Jan 30;24(1):54. doi: 10.1186/s12864-023-09155-1. BMC Genomics. 2023. PMID: 36717784 Free PMC article. - Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes.
Sharif M, Bangs JD. Sharif M, et al. mSphere. 2022 Aug 31;7(4):e0018822. doi: 10.1128/msphere.00188-22. Epub 2022 Jun 21. mSphere. 2022. PMID: 35727050 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources