Macrophage regulation of tumor responses to anticancer therapies - PubMed (original) (raw)

Review

. 2013 Mar 18;23(3):277-86.

doi: 10.1016/j.ccr.2013.02.013.

Affiliations

• PMID: 23518347
• DOI: 10.1016/j.ccr.2013.02.013

Free article

Review

Macrophage regulation of tumor responses to anticancer therapies

Michele De Palma et al. Cancer Cell. 2013.

Free article

Abstract

Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also shown that TAMs can either enhance or antagonize the antitumor efficacy of cytotoxic chemotherapy, cancer-cell targeting antibodies, and immunotherapeutic agents--depending on the type of treatment and tumor model. TAMs also drive reparative mechanisms in tumors after radiotherapy or treatment with vascular-targeting agents. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target TAMs to increase the efficacy of such therapies.

Copyright © 2013 Elsevier Inc. All rights reserved.

PubMed Disclaimer

Similar articles

• New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy.
  Guo Q, Jin Z, Yuan Y, Liu R, Xu T, Wei H, Xu X, He S, Chen S, Shi Z, Hou W, Hua B. Guo Q, et al. J Immunol Res. 2016;2016:9720912. doi: 10.1155/2016/9720912. Epub 2016 Nov 16. J Immunol Res. 2016. PMID: 27975071 Free PMC article. Review.
• Tumor-associated macrophages: A promising target for a cancer immunotherapeutic strategy.
  Zhang SY, Song XY, Li Y, Ye LL, Zhou Q, Yang WB. Zhang SY, et al. Pharmacol Res. 2020 Nov;161:105111. doi: 10.1016/j.phrs.2020.105111. Epub 2020 Oct 13. Pharmacol Res. 2020. PMID: 33065284 Review.
• Macrophage Polarization: Anti-Cancer Strategies to Target Tumor-Associated Macrophage in Breast Cancer.
  Tariq M, Zhang J, Liang G, Ding L, He Q, Yang B. Tariq M, et al. J Cell Biochem. 2017 Sep;118(9):2484-2501. doi: 10.1002/jcb.25895. Epub 2017 May 30. J Cell Biochem. 2017. PMID: 28106295 Review.
• Targeting tumor-associated macrophages: A potential treatment for solid tumors.
  Chen Y, Jin H, Song Y, Huang T, Cao J, Tang Q, Zou Z. Chen Y, et al. J Cell Physiol. 2021 May;236(5):3445-3465. doi: 10.1002/jcp.30139. Epub 2020 Nov 16. J Cell Physiol. 2021. PMID: 33200401 Review.
• Monocyte/macrophage infiltration in tumors: modulators of angiogenesis.
  Dirkx AE, Oude Egbrink MG, Wagstaff J, Griffioen AW. Dirkx AE, et al. J Leukoc Biol. 2006 Dec;80(6):1183-96. doi: 10.1189/jlb.0905495. Epub 2006 Sep 22. J Leukoc Biol. 2006. PMID: 16997855 Review.

Cited by

• Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer.
  Nakhlé J, Pierron V, Bauchet AL, Plas P, Thiongane A, Meyer-Losic F, Schmidlin F. Nakhlé J, et al. Oncoimmunology. 2016 Feb 18;5(6):e1145333. doi: 10.1080/2162402X.2016.1145333. eCollection 2016 Jun. Oncoimmunology. 2016. PMID: 27471612 Free PMC article.
• Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy.
  Ginefra P, Lorusso G, Vannini N. Ginefra P, et al. Int J Mol Sci. 2020 Jun 22;21(12):4441. doi: 10.3390/ijms21124441. Int J Mol Sci. 2020. PMID: 32580431 Free PMC article. Review.
• FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis.
  Qian BZ, Zhang H, Li J, He T, Yeo EJ, Soong DY, Carragher NO, Munro A, Chang A, Bresnick AR, Lang RA, Pollard JW. Qian BZ, et al. J Exp Med. 2015 Aug 24;212(9):1433-48. doi: 10.1084/jem.20141555. Epub 2015 Aug 10. J Exp Med. 2015. PMID: 26261265 Free PMC article.
• Advances in targeted and immunobased therapies for colorectal cancer in the genomic era.
  Seow HF, Yip WK, Fifis T. Seow HF, et al. Onco Targets Ther. 2016 Mar 31;9:1899-920. doi: 10.2147/OTT.S95101. eCollection 2016. Onco Targets Ther. 2016. PMID: 27099521 Free PMC article. Review.
• Dual CTLA-4 and PD-L1 Blockade Inhibits Tumor Growth and Liver Metastasis in a Highly Aggressive Orthotopic Mouse Model of Colon Cancer.
  Fiegle E, Doleschel D, Koletnik S, Rix A, Weiskirchen R, Borkham-Kamphorst E, Kiessling F, Lederle W. Fiegle E, et al. Neoplasia. 2019 Sep;21(9):932-944. doi: 10.1016/j.neo.2019.07.006. Epub 2019 Aug 11. Neoplasia. 2019. PMID: 31412307 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)