Characterization of ROS1 cDNA from a human glioblastoma cell line - PubMed (original) (raw)

Comparative Study

Characterization of ROS1 cDNA from a human glioblastoma cell line

C Birchmeier et al. Proc Natl Acad Sci U S A. 1990 Jun.

Abstract

We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarities in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmembrane tyrosine kinases.

PubMed Disclaimer

Similar articles

• Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing.
  Rodrigues GA, Naujokas MA, Park M. Rodrigues GA, et al. Mol Cell Biol. 1991 Jun;11(6):2962-70. doi: 10.1128/mcb.11.6.2962-2970.1991. Mol Cell Biol. 1991. PMID: 1710022 Free PMC article.
• Isolation and characterization of new mammalian kinase genes by cross hybridization with a tyrosine kinase probe.
  Shibuya M, Matsushime H, Yamane A, Ikeda T, Yoshida MC, Tojo A. Shibuya M, et al. Princess Takamatsu Symp. 1989;20:103-10. Princess Takamatsu Symp. 1989. PMID: 2562176
• Expression and rearrangement of the ROS1 gene in human glioblastoma cells.
  Birchmeier C, Sharma S, Wigler M. Birchmeier C, et al. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9270-4. doi: 10.1073/pnas.84.24.9270. Proc Natl Acad Sci U S A. 1987. PMID: 2827175 Free PMC article.
• ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway.
  Ou SH, Tan J, Yen Y, Soo RA. Ou SH, et al. Expert Rev Anticancer Ther. 2012 Apr;12(4):447-56. doi: 10.1586/era.12.17. Expert Rev Anticancer Ther. 2012. PMID: 22500682 Review.
• ROS1 fusions in cancer: a review.
  Uguen A, De Braekeleer M. Uguen A, et al. Future Oncol. 2016 Aug;12(16):1911-28. doi: 10.2217/fon-2016-0050. Epub 2016 Jun 3. Future Oncol. 2016. PMID: 27256160 Review.

Cited by

• ROS1 rearrangements define a unique molecular class of lung cancers.
  Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, Mark EJ, Batten JM, Chen H, Wilner KD, Kwak EL, Clark JW, Carbone DP, Ji H, Engelman JA, Mino-Kenudson M, Pao W, Iafrate AJ. Bergethon K, et al. J Clin Oncol. 2012 Mar 10;30(8):863-70. doi: 10.1200/JCO.2011.35.6345. Epub 2012 Jan 3. J Clin Oncol. 2012. PMID: 22215748 Free PMC article.
• New nucleotide sequence data on the EMBL File Server.
  [No authors listed] [No authors listed] Nucleic Acids Res. 1990 Sep 25;18(18):5587-605. doi: 10.1093/nar/18.18.5587. Nucleic Acids Res. 1990. PMID: 2216753 Free PMC article. No abstract available.
• Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.
  Jędraszek K, Malczewska M, Parysek-Wójcik K, Lejman M. Jędraszek K, et al. Int J Mol Sci. 2022 Mar 12;23(6):3067. doi: 10.3390/ijms23063067. Int J Mol Sci. 2022. PMID: 35328487 Free PMC article. Review.
• The Frequency and Clinical Implication of ROS1 and RET Rearrangements in Resected Stage IIIA-N2 Non-Small Cell Lung Cancer Patients.
  Fu S, Liang Y, Lin YB, Wang F, Huang MY, Zhang ZC, Wang J, Cen WJ, Shao JY. Fu S, et al. PLoS One. 2015 Apr 23;10(4):e0124354. doi: 10.1371/journal.pone.0124354. eCollection 2015. PLoS One. 2015. PMID: 25905642 Free PMC article.
• Targeted Therapy in Advanced and Metastatic Non-Small Cell Lung Cancer. An Update on Treatment of the Most Important Actionable Oncogenic Driver Alterations.
  König D, Savic Prince S, Rothschild SI. König D, et al. Cancers (Basel). 2021 Feb 15;13(4):804. doi: 10.3390/cancers13040804. Cancers (Basel). 2021. PMID: 33671873 Free PMC article. Review.

References

1. 1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
2. 1. Oncogene Res. 1989;5(2):91-100 - PubMed
3. 1. Cell. 1983 Nov;35(1):71-8 - PubMed
4. 1. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 - PubMed
5. 1. Nucleic Acids Res. 1984 Jan 25;12(2):857-72 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource