Signalling by the βc family of cytokines - PubMed (original) (raw)

Review

. 2013 Jun;24(3):189-201.

doi: 10.1016/j.cytogfr.2013.03.002. Epub 2013 Mar 25.

Urmi Dhagat, Winnie L T Kan, Sophie E Broughton, Tracy L Nero, Michelle Perugini, Jarrod J Sandow, Richard J D'Andrea, Paul G Ekert, Timothy Hughes, Michael W Parker, Angel F Lopez

Affiliations

• PMID: 23535386
• DOI: 10.1016/j.cytogfr.2013.03.002

Review

Signalling by the βc family of cytokines

Timothy R Hercus et al. Cytokine Growth Factor Rev. 2013 Jun.

Abstract

The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the βc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the βc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.

Keywords: Cytokines; Inflammation; Leukaemia; Signalling; β Common receptor.

Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

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