Functional cerebral imaging by susceptibility-contrast NMR - PubMed (original) (raw)

Functional cerebral imaging by susceptibility-contrast NMR

J W Belliveau et al. Magn Reson Med. 1990 Jun.

Abstract

In vivo measurement of cerebral physiology by dynamic contrast-enhanced NMR is demonstrated. Time-resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility-induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured.

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