The need for central and peripheral tolerance in the B cell repertoire - PubMed (original) (raw)

Comparative Study

. 1990 Jun 15;248(4961):1373-9.

doi: 10.1126/science.2356469.

Affiliations

• PMID: 2356469
• DOI: 10.1126/science.2356469

Comparative Study

The need for central and peripheral tolerance in the B cell repertoire

C C Goodnow et al. Science. 1990.

Abstract

The immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells. Unlike the T cell repertoire, antibody diversity is generated within the B cell repertoire in two phases; the first occurs by gene rearrangement in primary lymphoid organs, and the second phase involves antigen-driven hypermutation in peripheral lymphoid organs. The possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models, in which self-reactive B cells appear to be silenced both by functional inactivation and by physical elimination.

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