The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax - PubMed (original) (raw)
Affiliations
- PMID: 2359621
The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax
O Faktor et al. Oncogene. 1990 Jun.
Abstract
The human hepatitis B virus (HBV) X gene encodes a general transactivator which was suggested to be a potential factor in viral hepatocarcinogenesis. We show here that this protein transactivates the HBV enhancer linked either to the X gene promoter or heterologous promoters. Analysis of individual elements of the HBV enhancer revealed that the E element is sufficient to respond to X and is termed hence the X responsive element (XRE). Interestingly, XRE shares sequence similarity with the HTLV-I taxI responsive element (21 bp repeat or taxRE), and both elements bind similar nuclear proteins. The functional significance of this sequence similarity was demonstrated by the ability of XRE to respond to taxI. We also show that both X and taxI have the capacity to activate transcription through a second cis element, the NF-kappa B binding site. The response pattern of these viral regulators is also similar and both act in a concentration dependent manner. They are very active in low amounts, but almost inactive at high concentrations. Based on these observations, we suggest a common mechanism of action by regulator genes of distinct viruses.
Similar articles
- Activation of the HTLV-I long terminal repeat by the hepatitis B virus X protein.
Marriott SJ, Lee TH, Slagle BL, Butel JS. Marriott SJ, et al. Virology. 1996 Oct 1;224(1):206-13. doi: 10.1006/viro.1996.0522. Virology. 1996. PMID: 8862415 - Characterization of a specific region in the hepatitis B virus enhancer I for the efficient expression of X gene in the hepatic cell.
Fukai K, Takada S, Yokosuka O, Saisho H, Omata M, Koike K. Fukai K, et al. Virology. 1997 Sep 29;236(2):279-87. doi: 10.1006/viro.1997.8750. Virology. 1997. PMID: 9325235 - [Mechanism of hepatocarcinogenesis by hepatitis B virus].
Takada S, Koike K. Takada S, et al. Nihon Rinsho. 1993 Feb;51(2):364-9. Nihon Rinsho. 1993. PMID: 8385238 Review. Japanese. - Functional dissection of a viral transactivator.
Dingwall C. Dingwall C. Bioessays. 1991 Feb;13(2):85-6. doi: 10.1002/bies.950130207. Bioessays. 1991. PMID: 2029270 Review. No abstract available.
Cited by
- Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.
Natoli G, Avantaggiati ML, Chirillo P, Costanzo A, Artini M, Balsano C, Levrero M. Natoli G, et al. Mol Cell Biol. 1994 Feb;14(2):989-98. doi: 10.1128/mcb.14.2.989-998.1994. Mol Cell Biol. 1994. PMID: 7507209 Free PMC article. - Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.
Waris G, Huh KW, Siddiqui A. Waris G, et al. Mol Cell Biol. 2001 Nov;21(22):7721-30. doi: 10.1128/MCB.21.22.7721-7730.2001. Mol Cell Biol. 2001. PMID: 11604508 Free PMC article. - p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53.
Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y. Ori A, et al. EMBO J. 1998 Jan 15;17(2):544-53. doi: 10.1093/emboj/17.2.544. EMBO J. 1998. PMID: 9430645 Free PMC article. - Hepatitis B virus and hepatocellular carcinoma.
Arbuthnot P, Kew M. Arbuthnot P, et al. Int J Exp Pathol. 2001 Apr;82(2):77-100. doi: 10.1111/j.1365-2613.2001.iep0082-0077-x. Int J Exp Pathol. 2001. PMID: 11454100 Free PMC article. Review. - Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases.
Benn J, Su F, Doria M, Schneider RJ. Benn J, et al. J Virol. 1996 Aug;70(8):4978-85. doi: 10.1128/JVI.70.8.4978-4985.1996. J Virol. 1996. PMID: 8764004 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources