It's the peptide-MHC affinity, stupid - PubMed (original) (raw)
Comment
. 2013 Apr 15;23(4):429-31.
doi: 10.1016/j.ccr.2013.04.004.
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- PMID: 23597560
- DOI: 10.1016/j.ccr.2013.04.004
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Comment
It's the peptide-MHC affinity, stupid
Thomas Kammertoens et al. Cancer Cell. 2013.
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Abstract
Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
- Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Engels B, Engelhard VH, Sidney J, Sette A, Binder DC, Liu RB, Kranz DM, Meredith SC, Rowley DA, Schreiber H. Engels B, et al. Cancer Cell. 2013 Apr 15;23(4):516-26. doi: 10.1016/j.ccr.2013.03.018. Cancer Cell. 2013. PMID: 23597565 Free PMC article.
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