Mobile microbiome: oral bacteria in extra-oral infections and inflammation - PubMed (original) (raw)

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Mobile microbiome: oral bacteria in extra-oral infections and inflammation

Y W Han et al. J Dent Res. 2013 Jun.

Abstract

The link between oral infections and adverse systemic conditions has attracted much attention in the research community. Several mechanisms have been proposed, including spread of the oral infection due to transient bacteremia resulting in bacterial colonization in extra-oral sites, systemic injury by free toxins of oral pathogens, and systemic inflammation caused by soluble antigens of oral pathogens. Mounting evidence supports a major role of the systemic spread of oral commensals and pathogens to distant body sites causing extra-oral infections and inflammation. We review here the most recent findings on systemic infections and inflammation complicated by oral bacteria, including cardiovascular disease, adverse pregnancy outcomes, rheumatoid arthritis, inflammatory bowel disease and colorectal cancer, respiratory tract infections, and organ inflammations and abscesses. The recently identified virulence mechanisms of oral species Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Campylobacter rectus are also reviewed. A pattern emerges indicating that only select subtype(s) of a given species, e.g., F. nucleatum subspecies animalis and polymorphum and S. mutans non-c serotypes, are prone to extra-oral translocation. These findings advocate the importance of identification and quantification of potential pathogens at the subtype levels for accurate prediction of disease potential.

Keywords: Fusobacterium; Porphyromonas; bacteremia; pregnancy complications; systemic disease; virulence mechanism.

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Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.

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References

    1. Abranches J, Miller JH, Martinez AR, Simpson-Haidaris PJ, Burne RA, Lemos JA. (2011). The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells. Infect Immun 79:2277-2284. - PMC - PubMed
    1. Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. (2007). Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 13:134-137. - PubMed
    1. Arce RM, Barros SP, Wacker B, Peters B, Moss K, Offenbacher S. (2009). Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens. Placenta 30:156-162. - PMC - PubMed
    1. Arce RM, Diaz PI, Barros SP, Galloway P, Bobetsis Y, Threadgill D, et al. (2010). Characterization of the invasive and inflammatory traits of oral Campylobacter rectus in a murine model of fetoplacental growth restriction and in trophoblast cultures. J Reprod Immunol 84:145-153. - PMC - PubMed
    1. Arce RM, Caron KM, Barros SP, Offenbacher S. (2012). Toll-like receptor 4 mediates intrauterine growth restriction after systemic Campylobacter rectus infection in mice. Mol Oral Microbiol 27:373-381. - PMC - PubMed

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