Neuregulin 3 and erbb signalling networks in embryonic mammary gland development - PubMed (original) (raw)

Review

Neuregulin 3 and erbb signalling networks in embryonic mammary gland development

Naoko Kogata et al. J Mammary Gland Biol Neoplasia. 2013 Jun.

Abstract

We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.

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