Structural, evolutionary, and assembly principles of protein oligomerization - PubMed (original) (raw)
Review
Structural, evolutionary, and assembly principles of protein oligomerization
Emmanuel D Levy et al. Prog Mol Biol Transl Sci. 2013.
Abstract
In the protein universe, 30-50% of proteins self-assemble to form symmetrical complexes consisting of multiple copies of themselves, called homomers. The prevalence of homomers motivates us to review many of their properties. In Section 1, we describe the methods and challenges associated with quaternary structure inference-these methods are indeed at the basis of any analysis on homomers. In Section 2, we describe the morphological properties of homomers, as well as the database 3DComplex, which provides a taxonomy for both homomeric and heteromeric protein complexes. In Section 3, we review interface properties of homomeric complexes. In Section 4, we then present recent findings on the evolution of homomer interfaces, which we link in Section 5 to the evolution of homomers as entire entities. In Section 6, we discuss mechanisms involved in their assembly and how these mechanisms can be linked to evolution.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
- Structure, dynamics, assembly, and evolution of protein complexes.
Marsh JA, Teichmann SA. Marsh JA, et al. Annu Rev Biochem. 2015;84:551-75. doi: 10.1146/annurev-biochem-060614-034142. Epub 2014 Dec 8. Annu Rev Biochem. 2015. PMID: 25494300 Review. - Geometric description of self-interaction potential in symmetric protein complexes.
Empereur-Mot C, Garcia-Seisdedos H, Elad N, Dey S, Levy ED. Empereur-Mot C, et al. Sci Data. 2019 May 17;6(1):64. doi: 10.1038/s41597-019-0058-x. Sci Data. 2019. PMID: 31101822 Free PMC article. - Assembly reflects evolution of protein complexes.
Levy ED, Boeri Erba E, Robinson CV, Teichmann SA. Levy ED, et al. Nature. 2008 Jun 26;453(7199):1262-5. doi: 10.1038/nature06942. Epub 2008 Jun 18. Nature. 2008. PMID: 18563089 Free PMC article. - Functional determinants of protein assembly into homomeric complexes.
Bergendahl LT, Marsh JA. Bergendahl LT, et al. Sci Rep. 2017 Jul 10;7(1):4932. doi: 10.1038/s41598-017-05084-8. Sci Rep. 2017. PMID: 28694495 Free PMC article. - Protein interactions in 3D: from interface evolution to drug discovery.
Winter C, Henschel A, Tuukkanen A, Schroeder M. Winter C, et al. J Struct Biol. 2012 Sep;179(3):347-58. doi: 10.1016/j.jsb.2012.04.009. Epub 2012 May 1. J Struct Biol. 2012. PMID: 22595401 Review.
Cited by
- Single-molecule digital sizing of proteins in solution.
Krainer G, Jacquat RPB, Schneider MM, Welsh TJ, Fan J, Peter QAE, Andrzejewska EA, Šneiderienė G, Czekalska MA, Ausserwoeger H, Chai L, Arter WE, Saar KL, Herling TW, Franzmann TM, Kosmoliaptsis V, Alberti S, Hartl FU, Lee SF, Knowles TPJ. Krainer G, et al. Nat Commun. 2024 Sep 4;15(1):7740. doi: 10.1038/s41467-024-50825-9. Nat Commun. 2024. PMID: 39231922 Free PMC article. - Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.
Szyszka TN, Andreas MP, Lie F, Miller LM, Adamson LSR, Fatehi F, Twarock R, Draper BE, Jarrold MF, Giessen TW, Lau YH. Szyszka TN, et al. Proc Natl Acad Sci U S A. 2024 May 14;121(20):e2321260121. doi: 10.1073/pnas.2321260121. Epub 2024 May 9. Proc Natl Acad Sci U S A. 2024. PMID: 38722807 - Agglomeration: when folded proteins clump together.
Romero-Romero ML, Garcia-Seisdedos H. Romero-Romero ML, et al. Biophys Rev. 2023 Dec 15;15(6):1987-2003. doi: 10.1007/s12551-023-01172-4. eCollection 2023 Dec. Biophys Rev. 2023. PMID: 38192350 Free PMC article. Review. - Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors.
Liu S, Abboud M, Mikhailov V, Liu X, Reinbold R, Schofield CJ. Liu S, et al. J Med Chem. 2023 Apr 13;66(7):5279-5288. doi: 10.1021/acs.jmedchem.3c00203. Epub 2023 Mar 23. J Med Chem. 2023. PMID: 36952395 Free PMC article. - Oligomerization of peripheral membrane proteins provides tunable control of cell surface polarity.
Lang CF, Munro EM. Lang CF, et al. Biophys J. 2022 Dec 6;121(23):4543-4559. doi: 10.1016/j.bpj.2022.10.035. Epub 2022 Oct 29. Biophys J. 2022. PMID: 36815706 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources