Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue - PubMed (original) (raw)
Case Reports
doi: 10.1159/000132910.
Affiliations
- PMID: 2369838
- DOI: 10.1159/000132910
Case Reports
Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue
P Elfving et al. Cytogenet Cell Genet. 1990.
Abstract
Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss of the Y chromosome were described in cultures from nonneoplastic tissue, making the significance of these aberrations as cancer-associated changes doubtful. We herein report the mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue. Smaller clones with trisomy 10 were present in three cases, and the only culture established from a male also showed mosaic loss of the Y chromosome.
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