Neuroticism and common mental disorders: meaning and utility of a complex relationship - PubMed (original) (raw)

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Neuroticism and common mental disorders: meaning and utility of a complex relationship

Johan Ormel et al. Clin Psychol Rev. 2013 Jul.

Abstract

Neuroticism's prospective association with common mental disorders (CMDs) has fueled the assumption that neuroticism is an independent etiologically informative risk factor. This vulnerability model postulates that neuroticism sets in motion processes that lead to CMDs. However, four other models seek to explain the association, including the spectrum model (manifestations of the same process), common cause model (shared determinants), state and scar models (CMD episode adds temporary/permanent neuroticism). To examine their validity we reviewed literature on confounding, operational overlap, stability and change, determinants, and treatment effects. None of the models is able to account for (virtually) all findings. The state and scar model cannot explain the prospective association. The spectrum model has some relevance, especially for internalizing disorders. Common causes are most important but the vulnerability model cannot be excluded although confounding of the prospective association by baseline symptoms and psychiatric history is substantial. In fact, some of the findings, such as interactions with stress and the small decay of neuroticism's effect over time, are consistent with the vulnerability model. We describe research designs that discriminate the remaining models and plea for deconstruction of neuroticism. Neuroticism is etiologically not informative yet but useful as an efficient marker of non-specified general risk.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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Figure 1

Tentative model of the relationship between neuroticism and CMDs disorders

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References

    1. Allen B, Lauterbach D. Personality characteristics of adult survivors of childhood trauma. Journal of Traumatic Stress. 2007;20(4):587–595. - PubMed
    1. American Psychiatric Association . Diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) American Psychiatric Association; Washington DC: 1994.
    1. Bolger N, Schilling EA. Personality and the problems of everyday life: The role of neuroticism in exposure and reactivity to daily stressors. Journal of Personality. 1991;59(3):355–386. - PubMed
    1. Boomsma DI, van Beijsterveldt CE, Hudziak JJ. Genetic and environmental influences on Anxious/Depression during childhood: A study from the netherlands twin register. Genes, Brain, and Behavior. 2005;4(8):466–481. doi: 10.1111/j.1601-183X.2005.00141.x. - PubMed
    1. Borenstein M. In: Effect sizes for continuous data. Cooper H, Hedges LV, Valentine JC, editors. Russell Sage Foundation; New York, NY US: 2009. pp. 221–235. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05060....

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