Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice - PubMed (original) (raw)
Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice
H Carlsten et al. Clin Exp Immunol. 1990 Jun.
Abstract
The influence of oestrogen on the lupus disease in MRL/l mice has been investigated. Adult, castrated male and female MRL/l mice were administered with s.c. injections of 3.2 micrograms of 17 beta-oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a potent accelerator of the lupus disease in this mouse strain. Thus, administration of oestrogen accelerates glomerulonephritis, lymphoproliferation and mortality. Our results also indicate that oestrogen exerts a dual effect on the immune system of MRL/l mice by depression of antigen-specific and mitogen-induced T cell responses as well as enhancement of polyclonal B cell activation and autoantibody formation. In addition, even short-term administration of oestrogen in the preclinical phase of the disease resulted in long-lasting effects as evaluated by reduced longevity and aggravation of renal disease.
Similar articles
- Histocompatibility complex gene products and exposure to oestrogen: two independent disease accelerating factors in murine lupus.
Carlsten H, Tarkowski A. Carlsten H, et al. Scand J Immunol. 1993 Oct;38(4):341-7. doi: 10.1111/j.1365-3083.1993.tb01736.x. Scand J Immunol. 1993. PMID: 8210997 - Expression of heterozygous lpr gene in MRL mice. II. Acceleration of glomerulonephritis, sialadenitis, and autoantibody production.
Carlsten H, Tarkowski A, Jonsson R, Nilsson LA. Carlsten H, et al. Scand J Immunol. 1990 Jul;32(1):21-8. doi: 10.1111/j.1365-3083.1990.tb02887.x. Scand J Immunol. 1990. PMID: 2382106 - B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus.
Wen J, Doerner J, Chalmers S, Stock A, Wang H, Gullinello M, Shlomchik MJ, Putterman C. Wen J, et al. J Neuroinflammation. 2016 Apr 7;13(1):73. doi: 10.1186/s12974-016-0537-3. J Neuroinflammation. 2016. PMID: 27055816 Free PMC article. - Dysregulated Lymphoid Cell Populations in Mouse Models of Systemic Lupus Erythematosus.
De Groof A, Hémon P, Mignen O, Pers JO, Wakeland EK, Renaudineau Y, Lauwerys BR. De Groof A, et al. Clin Rev Allergy Immunol. 2017 Oct;53(2):181-197. doi: 10.1007/s12016-017-8605-8. Clin Rev Allergy Immunol. 2017. PMID: 28500565 Review.
Cited by
- Increased development of T-bet+CD11c+ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses.
Sullivan KA, Chapman C, Lu L, Ashbrook DG, Wang Y, Alduraibi FK, Lu C, Sun CW, Liu S, Williams RW, Mountz JD, Hsu HC. Sullivan KA, et al. Clin Immunol. 2023 Dec;257:109842. doi: 10.1016/j.clim.2023.109842. Epub 2023 Nov 18. Clin Immunol. 2023. PMID: 37981105 - A tissue-selective estrogen complex as treatment of osteoporosis in experimental lupus.
Nordqvist J, Engdahl C, Scheffler JM, Gupta P, Gustafsson KL, Lagerquist MK, Carlsten H, Islander U. Nordqvist J, et al. Lupus. 2022 Feb;31(2):143-154. doi: 10.1177/09612033211067984. Epub 2022 Jan 21. Lupus. 2022. PMID: 35062848 Free PMC article. - Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination.
Voigt EA, Ovsyannikova IG, Kennedy RB, Grill DE, Goergen KM, Schaid DJ, Poland GA. Voigt EA, et al. Front Immunol. 2019 Feb 27;10:180. doi: 10.3389/fimmu.2019.00180. eCollection 2019. Front Immunol. 2019. PMID: 30873150 Free PMC article. - Complete knockout of estrogen receptor alpha is not directly protective in murine lupus.
Scott JL, Wirth JR, Eudaly J, Ruiz P, Cunningham MA. Scott JL, et al. Clin Immunol. 2017 Oct;183:132-141. doi: 10.1016/j.clim.2017.08.010. Epub 2017 Aug 16. Clin Immunol. 2017. PMID: 28822833 Free PMC article. - Early Ovariectomy Results in Reduced Numbers of CD11c+/CD11b+ Spleen Cells and Impacts Disease Expression in Murine Lupus.
Cunningham MA, Wirth JR, Scott JL, Eudaly J, Collins EL, Gilkeson GS. Cunningham MA, et al. Front Immunol. 2016 Feb 15;7:31. doi: 10.3389/fimmu.2016.00031. eCollection 2016. Front Immunol. 2016. PMID: 26913030 Free PMC article.
References
- J Immunol Methods. 1983 Dec 16;65(1-2):109-21 - PubMed
- Clin Immunol Immunopathol. 1984 Apr;31(1):65-77 - PubMed
- Immunol Rev. 1984 Apr;78:159-83 - PubMed
- Endocr Rev. 1984 Summer;5(3):435-55 - PubMed
- Clin Exp Immunol. 1984 Oct;58(1):7-12 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases