Hodgkin lymphoma in pregnancy - PubMed (original) (raw)

Hodgkin lymphoma in pregnancy

Veronika Bachanova et al. Curr Hematol Malig Rep. 2013 Sep.

Abstract

The peak incidence of Hodgkin lymphoma (HL) coincides with reproductive years, and as many as 3 % of all HL patients present with concurrent pregnancy. The management of a pregnant patient with HL requires a multidisciplinary approach combining expertise in medical oncology, high-risk obstetrics, and neonatology, as well as effective communication with the patient and her family. The goal is to optimize the mother's chance of a cure while allowing for delivery of a healthy child. A pregnant patient with HL should be staged by clinical examination and judicious use of non-radiation imaging such as ultrasound, balancing the need for accurate disease assessment with the need to minimize invasive procedures. The treatment strategy is individualized to the symptoms, lymphoma stage, gestational age and the patients' wishes. Therapeutic options include treatment deferral or single-agent vinblastine with reservation of multi-agent chemotherapy until the second or third trimester for the small minority of patients with aggressive clinical presentation.

PubMed Disclaimer

Figures

Fig. 1

Recommended algorithm for treatment of pregnancy-associated Hodgkin lymphoma (HL) ABVD doxorubicin, bleomycin, vinblastine, dacarbazine

Similar articles

• Hodgkin lymphoma in the elderly, pregnant, and HIV-infected.
  Bachanova V, Connors JM. Bachanova V, et al. Semin Hematol. 2016 Jul;53(3):203-8. doi: 10.1053/j.seminhematol.2016.05.002. Epub 2016 May 17. Semin Hematol. 2016. PMID: 27496312 Free PMC article. Review.
• Challenging problems: coincident pregnancy, HIV infection, and older age.
  Connors JM. Connors JM. Hematology Am Soc Hematol Educ Program. 2008:334-9. doi: 10.1182/asheducation-2008.1.334. Hematology Am Soc Hematol Educ Program. 2008. PMID: 19074106
• The management of hodgkin lymphomas in pregnancies.
  Moshe Y, Bentur OS, Lishner M, Avivi I. Moshe Y, et al. Eur J Haematol. 2017 Nov;99(5):385-391. doi: 10.1111/ejh.12956. Epub 2017 Oct 5. Eur J Haematol. 2017. PMID: 28850718 Review.
• Management and controversies of classical Hodgkin lymphoma in pregnancy.
  Eyre TA, Lau IJ, Mackillop L, Collins GP. Eyre TA, et al. Br J Haematol. 2015 Jun;169(5):613-30. doi: 10.1111/bjh.13327. Epub 2015 Feb 13. Br J Haematol. 2015. PMID: 25684034 Review.
• [Hodgkin's disease in pregnancy--case report and literature review].
  Schäffer M, Hegenbart U, Klostermann K, Stepan H. Schäffer M, et al. Z Geburtshilfe Neonatol. 2003 Mar-Apr;207(2):71-3. doi: 10.1055/s-2003-39153. Z Geburtshilfe Neonatol. 2003. PMID: 12740750 German.

Cited by

• Leukemia in pregnancy: Diagnosis and therapeutic approach (Review).
  Giannakaki AG, Giannakaki MN, Oikonomou E, Nikolettos K, Bothou A, Kotanidou S, Andreou S, Kritsotaki N, Nalmpanti T, Spanoudakis E, Iatrakis G, Damaskos C, Garmpis N, Nikolettos N, Tsikouras P. Giannakaki AG, et al. Mol Clin Oncol. 2024 Aug 21;21(5):79. doi: 10.3892/mco.2024.2777. eCollection 2024 Nov. Mol Clin Oncol. 2024. PMID: 39246846 Free PMC article. Review.
• Imaging evaluation of lymphoma in pregnancy with review of clinical assessment and treatment options.
  Dell'Aquila K, Hodges H, Moshiri M, Katz DS, Elojeimy S, Revzin MV, Tembelis M, Revels JW. Dell'Aquila K, et al. Abdom Radiol (NY). 2023 May;48(5):1663-1678. doi: 10.1007/s00261-022-03779-9. Epub 2023 Jan 3. Abdom Radiol (NY). 2023. PMID: 36595067 Free PMC article. Review.
• Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: A systematic review.
  Houlihan OA, Buckley D, Maher GM, McCarthy FP, Khashan AS. Houlihan OA, et al. BJOG. 2023 Mar;130(4):336-347. doi: 10.1111/1471-0528.17347. Epub 2022 Dec 12. BJOG. 2023. PMID: 36424902 Free PMC article. Review.
• Unusual Presentation of Hodgkin's Lymphoma in Pregnancy: A Case Report and Systematic Review of Literature.
  Delzotto J, Naqvi TS, Opara NU, Delzotto A, Morgan A. Delzotto J, et al. Hematol Rep. 2022 Nov 3;14(4):322-334. doi: 10.3390/hematolrep14040046. Hematol Rep. 2022. PMID: 36412626 Free PMC article.
• Cancer Treatment and Immunotherapy during Pregnancy.
  Koutras A, Ntounis T, Fasoulakis Z, Papalios T, Pittokopitou S, Prokopakis I, Syllaios A, Valsamaki A, Chionis A, Symeonidis P, Samara AA, Pagkalos A, Pergialiotis V, Theodora M, Antsaklis P, Daskalakis G, Kontomanolis EN. Koutras A, et al. Pharmaceutics. 2022 Sep 29;14(10):2080. doi: 10.3390/pharmaceutics14102080. Pharmaceutics. 2022. PMID: 36297515 Free PMC article. Review.

References

1. 1. Smith LH, Danielsen B, Allen ME, Cress R. Cancer associated with obstetric delivery: results of linkage with the California cancer registry. Am J Obstet Gynecol. 2003;189:1128–35. - PubMed
2. 1. Connors JM. Clinical manifestations and natural history of Hodgkin’s lymphoma. Cancer J. 2009;15:124–8. - PubMed
3. 1. Connors JM. Challenging problems: coincident pregnancy, HIV infection, and older age. Hematol Am Soc Hematol Educ Program. 2008:334–9. - PubMed
4. 1. Bachanova V, Connors JM. How is Hodgkin lymphoma in pregnancy best treated? ASH evidence-based review 2008. Hematol Am Soc Hematol Educ Program. 2008:33–4. - PubMed
5. 1. Zanotti-Fregonara P, Jan S, Taieb D, et al. Absorbed 18F-FDG dose to the fetus during early pregnancy. J Nucl Med. 2010;51:803–5. Impact of PET/CT imaging on pregnancy. - PubMed

MeSH terms

Substances

Supplementary concepts

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Springer

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information