The trajectory of depressive symptoms across the adult life span - PubMed (original) (raw)

The trajectory of depressive symptoms across the adult life span

Angelina R Sutin et al. JAMA Psychiatry. 2013 Aug.

Abstract

Importance: Long-term longitudinal studies are needed to delineate the trajectory of depressive symptoms across adulthood and to individuate factors that may contribute to increases in depressive symptoms in older adulthood.

Objectives: To estimate the trajectory of depressive symptoms across the adult life span; to test whether this trajectory varies by demographic factors (sex, ethnicity, and educational level) and antidepressant medication use; and to test whether disease burden, functional limitations, and proximity to death explain the increase in depressive symptoms in old age.

Design: Longitudinal study.

Setting: Community.

Participants: The study included 2320 participants (47.0% female; mean [SD] age at baseline, 58.1 [17.0] years; range, 19-95 years) from the Baltimore Longitudinal Study of Aging.

Main outcomes and measures: Estimated trajectory of depressive symptoms modeled from 10, 982 assessments (mean [SD] assessments per participant, 4.7 [3.6]; range, 1-21) based on the Center for Epidemiologic Studies Depression scale and 3 subscales (depressed affect, somatic complaints, and interpersonal problems).

Results: The linear (γ10 = 0.52; P < .01) and quadratic (γ20 = 0.43; P < .01) terms were significant, which indicated that depressive symptoms were highest in young adulthood, decreased across middle adulthood, and increased again in older adulthood. The subscales followed a similar pattern. Women reported more depressed affect at younger ages, but an interaction with age suggested that this gap disappeared in old age. Accounting for comorbidity, functional limitations, and impending death slightly reduced but did not eliminate the uptick in depressive symptoms in old age.

Conclusions and relevance: Symptoms of depression follow a U-shaped pattern across adulthood. Older adults experience an increase in distress that is not due solely to declines in physical health or approaching death.

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Conflict of interest statement

Conflict of interest: The authors have no conflict of interest to report.

Figures

Figure 1

Figure 1

Estimated trajectory of the CES-D total scale score and the three subscales across adulthood. Raw scored were z-transformed so that all scales could be plotted on the same axis. Supplemental Figure 1 shows the estimated trajectories of each scale in the original metric.

Figure 2

Figure 2

Estimated trajectory of depressed affect by sex.

Figure 3

Figure 3

Estimated trajectory of somatic complaints in old age by participants still living and participants who died.

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