Oxidative stress in the pathogenesis of colorectal cancer: cause or consequence? - PubMed (original) (raw)

Review

Oxidative stress in the pathogenesis of colorectal cancer: cause or consequence?

Martina Perše. Biomed Res Int. 2013.

Abstract

There is a growing support for the concept that reactive oxygen species, which are known to be implicated in a range of diseases, may be important progenitors in carcinogenesis, including colorectal cancer (CRC). CRC is one of the most common cancers worldwide, with the highest incidence rates in western countries. Sporadic human CRC may be attributable to various environmental and lifestyle factors, such as dietary habits, obesity, and physical inactivity. In the last decades, association between oxidative stress and CRC has been intensively studied. Recently, numerous genetic and lifestyle factors that can affect an individual's ability to respond to oxidative stress have been identified. The aim of this paper is to review evidence linking oxidative stress to CRC and to provide essential background information for accurate interpretation of future research on oxidative stress and CRC risk. Brief introduction of different endogenous and exogenous factors that may influence oxidative status and modulate the ability of gut epithelial cells to cope with damaging metabolic challenges is also provided.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Shematic representation of the colonic barrier and intracellular protective mechanisms against oxidative stress.

Similar articles

Cited by

References

    1. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology. 2007;39(1):44–84. - PubMed
    1. Cejas P, Casado E, Belda-Iniesta C, et al. Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain) Cancer Causes and Control. 2004;15(7):707–719. - PubMed
    1. Mena S, Ortega A, Estrela JM. Oxidative stress in environmental-induced carcinogenesis. Mutation Research. 2009;674(1-2):36–44. - PubMed
    1. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biological Interactions. 2006;160(1):1–40. - PubMed
    1. Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutation Research. 1999;424(1-2):83–95. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources