Succinate: a new epigenetic hacker - PubMed (original) (raw)
Comment
. 2013 Jun 10;23(6):709-11.
doi: 10.1016/j.ccr.2013.05.015.
Affiliations
- PMID: 23763995
- DOI: 10.1016/j.ccr.2013.05.015
Free article
Comment
Succinate: a new epigenetic hacker
Ming Yang et al. Cancer Cell. 2013.
Free article
Abstract
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
- SDH mutations establish a hypermethylator phenotype in paraganglioma.
Letouzé E, Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, Janin M, Menara M, Nguyen AT, Benit P, Buffet A, Marcaillou C, Bertherat J, Amar L, Rustin P, De Reyniès A, Gimenez-Roqueplo AP, Favier J. Letouzé E, et al. Cancer Cell. 2013 Jun 10;23(6):739-52. doi: 10.1016/j.ccr.2013.04.018. Epub 2013 May 23. Cancer Cell. 2013. PMID: 23707781
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources