Dysregulated left inferior parietal activity in schizophrenia and depression: functional connectivity and characterization - PubMed (original) (raw)

Dysregulated left inferior parietal activity in schizophrenia and depression: functional connectivity and characterization

Veronika I Müller et al. Front Hum Neurosci. 2013.

Abstract

The inferior parietal cortex (IPC) is a heterogeneous region that is known to be involved in a multitude of diverse different tasks and processes, though its contribution to these often-complex functions is yet poorly understood. In a previous study we demonstrated that patients with depression failed to deactivate the left IPC during processing of congruent audiovisual information. We now found the same dysregulation (same region and condition) in schizophrenia. By using task-independent (resting state) and task-dependent meta-analytic connectivity modeling (MACM) analyses we aimed at characterizing this particular region with regard to its connectivity and function. Across both approaches, results revealed functional connectivity of the left inferior parietal seed region with bilateral IPC, precuneus and posterior cingulate cortex (PrC/PCC), medial orbitofrontal cortex (mOFC), left middle frontal (MFG) as well as inferior frontal (IFG) gyrus. Network-level functional characterization further revealed that on the one hand, all interconnected regions are part of a network involved in memory processes. On the other hand, sub-networks are formed when emotion, language, social cognition and reasoning processes are required. Thus, the IPC-region that is dysregulated in both depression and schizophrenia is functionally connected to a network of regions which, depending on task demands may form sub-networks. These results therefore indicate that dysregulation of left IPC in depression and schizophrenia might not only be connected to deficits in audiovisual integration, but is possibly also associated to impaired memory and deficits in emotion processing in these patient groups.

Keywords: depression; functional connectivity; inferior parietal cortex; resting-state; schizophrenia.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Significant interaction between incongruence × group in left inferior parietal cortex in depression (blue) and schizophrenia (red). The overlap of both activations served as seed area (purple) for functional connectivity calculation.

Figure 2

Figure 2

Results of the task-dependent (A), task-independent (B) analysis as well as the conjunction across both approaches (C). (A) Task-dependent functional connectivity of the seed region with bilateral parietal cortex extending into middle temporal and middle occipital gyri, with posterior cingulate cortex and precuneus, medial orbitofrontal cortex, left inferior frontal gyrus, left middle/superior frontal gyrus and left middle temporal gyrus. (B) Task-independent functional connectivity of the seed with bilateral parietal cortex extending into lateral occipital und temporal gyrus, precuneus and posterior cingulate cortex, as well as with bilateral cerebellum, hippocampus, parahippocampal gyrus, thalamus, fusiform gyrus, inferior and middle temporal gyrus, middle frontal gyrus, left inferior frontal gyrus, and medial orbitofrontal cortex. (C) Conjunction of task-dependent and task-independent connectivity reveals significant functional connectivity of the seed area with bilateral inferior parietal cortex, precuneus and posterior cingulate cortex, left middle and inferior frontal gyrus and medial orbitofrontal cortex.

Figure 3

Figure 3

Significant behavioral domains and paradigm classes for the different sub-networks revealed by forward (red) and reverse inference (blue). Details can be found in the result section “Functional characterization of derived networks”.

Similar articles

Cited by

References

    1. Amunts K., Kedo O., Kindler M., Pieperhoff P., Mohlberg H., Shah N. J., et al. (2005). Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anat. Embryol. (Berl.) 210, 343–352 10.1007/s00429-005-0025-5 - DOI - PubMed
    1. Amunts K., Schleicher A., Burgel U., Mohlberg H., Uylings H. B., Zilles K. (1999). Broca's region revisited: cytoarchitecture and intersubject variability. J. Comp. Neurol. 412, 319–341 10.1002/(SICI)1096-9861(19990920)412:2<319::AID-CNE10>3.0.CO;2-7 - DOI - PubMed
    1. Arsalidou M., Taylor M. J. (2011). Is 2+2=4? Meta-analyses of brain areas needed for numbers and calculations. Neuroimage 54, 2382–2393 10.1016/j.neuroimage.2010.10.009 - DOI - PubMed
    1. Ashburner J., Friston K. J. (2005). Unified segmentation. Neuroimage 26, 839–851 10.1016/j.neuroimage.2005.02.018 - DOI - PubMed
    1. Bach D. R., Buxtorf K., Grandjean D., Strik W. K. (2009). The influence of emotion clarity on emotional prosody identification in paranoid schizophrenia. Psychol. Med. 39, 927–938 10.1017/S0033291708004704 - DOI - PubMed

LinkOut - more resources