Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls - PubMed (original) (raw)

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Shelli R Kesler et al. Proc Natl Acad Sci U S A. 2013.

Abstract

Breast cancer (BC) chemotherapy is associated with cognitive changes including persistent deficits in some individuals. We tested the accuracy of default mode network (DMN) resting state functional connectivity patterns in discriminating chemotherapy treated (C+) from non-chemotherapy (C-) treated BC survivors and healthy controls (HC). We also examined the relationship between DMN connectivity patterns and cognitive function. Multivariate pattern analysis was used to classify 30 C+, 27 C-, and 24 HC, which showed significant accuracy for discriminating C+ from C- (91.23%, P < 0.0001) and C+ from HC (90.74%, P < 0.0001). The C- group did not differ significantly from HC (47.06%, P = 0.60). Lower subjective memory function was correlated (P < 0.002) with greater hyperplane distance (distance from the linear decision function that optimally separates the groups). Disrupted DMN connectivity may help explain long-term cognitive difficulties following BC chemotherapy.

Keywords: fMRI; machine learning.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.

Fig. 1.

Multivariate pattern classification of DMN intrinsic connectivity in C+ compared with C−. The graph shows connections specific to the C+ vs. C− classifier (solid lines) as well as those that were common between the C+ vs. C− and C+ vs. HC classifiers (dashed lines). Warmer colors correspond to higher absolute weights in the discrimination between C+ and C−. CBLM, cerebellum; LMFG, left middle frontal gyrus; LPCC, left precuneus; LPCNG, left precuneus/posterior cingulate; LPHP, left parahippocampus; MCNG, medial cingulate; MF, medial frontal; MPCC, medial precuneus; PCNG, posterior cingulate; RLP, right lateral parietal; RPCNG: right posterior cingulate; RPHP, right parahippocampus; RSFG, right superior frontal gyrus.

Fig. 2.

Fig. 2.

Multivariate pattern classification of DMN intrinsic connectivity in C+ compared with HC. The graph shows connections specific to the C+ vs. HC classifier (solid lines) as well as those that were common between the C+ vs. HC and C+ vs. C− classifiers (dashed lines). Warmer colors correspond to higher absolute weights in the discrimination between C+ and HC. LLP, left lateral parietal; THL, thalamus.

Fig. 3.

Fig. 3.

Correlation between hyperplane distance and self-rated memory ability. A significant negative correlation was observed within the (A) C+ vs. C− as well as the (B) C+ vs. HC classifiers.

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