Evaluation of bone loss in diabetic postmenopausal women - PubMed (original) (raw)

. 2012 Nov;17(11):1033-8.

Affiliations

• PMID: 23833577
• PMCID: PMC3702084

Evaluation of bone loss in diabetic postmenopausal women

Mansoor Karimifar et al. J Res Med Sci. 2012 Nov.

Abstract

Background: Osteoporosis and diabetes mellitus are major and growing public health problems particularly among postmenopausal women. This study was conducted to evaluate the relationship between osteoporosis and osteopenia with type 2 diabetes mellitus (DM) in postmenopausal women.

Materials and methods: In a cross sectional study, we compared 200 diabetic postmenopausal women with 400 non-diabetic postmenopausal women over the age of 60 years. Age, Body Mass Index (BMI), T score of the lumbar vertebra (L2-L4) and femoral neck were measured with Dual Energy X-ray Absorptiometry (DXA) and were compared between the two groups. Hemoglobin A1C (HbA1C) was also measured in patients with type 2 DM and its relationship with osteoporosis was studied. Chi-square, Fisher's exact test and Independent T-test was used for analyzing the data. The statistical significance was set at a P value of 0.05 or lower.

Results: Mean, SD ages were 65.23 ± 4.80 vs. 66.91 ± 5.78 years and BMI were 28.94 ± 4.06 vs. 31.65 ± 4.42 kg/m(2) in non-diabetic and diabetic groups, respectively. Lumber T scores was -2.10 ± 1.08 vs.-2.16 ± 1.27 (P = 0.60), femoral neck T-score was -0.72 ± 1.00 vs. -1.09 ± 0.96 (P = 0.00) in non-diabetic and diabetic groups, respectively. There was a significant difference in femoral neck T score between the diabetic and non-diabetic group (P = 0.00). In diabetic women, bone loss was more common in those with HbA1C ≥7 compare to those with HbA1C <7 (P = 0.006).

Conclusion: Osteopenia and osteoporosis is more common in diabetic postmenopausal women compare to the non-diabetic postmenopausal women.

Keywords: Diabetes mellitus; Osteoporosis; postmenopausal women.

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Conflict of interest statement

Conflict of Interest: None declared.

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References

1. 1. Begheri P, Haghdost AA, Dortaj RE, Halimi L, Vafaee Z, Farhangnia M, et al. Ultra analysis of prevalence of osteoporosis in Iranian women (A systematic review and meta-analysis) Iran J Endocrin Methabol. 2011;3:315–25.
2. 1. Soheili Azad AA, Golestan B, Jahanbakhsh S. Determination of the relation between osteoporotic and osteopenic risk factors among women referring to bone mineral density center, Baharloo Hospital. J Iran Univ Med Sci. 2008;14:91–9.
3. 1. Mohammad Zadeh NA, Najafipoor F, Bahrami A, Niafar M, Begler L, Haji Eghrari H, et al. Evaluation of decrease bone mineral density in osteoporotic and osteopenic women. J Gorgan Univ Med Sci. 2010;11:61–7.
4. 1. Jamshidian-Taheri M, Kalantari N, Azadbakht L, Esmaiel Zadeh A, Rajaie A, Hoshiar-Rad A. Risk Factors of osteoporosis in Tehrani women aged 40-60 years old. Iran J Endocr Methabol. 2007;6:139–45.
5. 1. Samere A. Tehran, Iran: Tehran University of Medical Science; 2005. Evaluation of usage preventing of osteoporotic behavior in menopausal women. Bulletin of 1st International congress of prevention, diagnosis and treatment; pp. 106–16.

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