Insights into TREM2 biology by network analysis of human brain gene expression data - PubMed (original) (raw)

• Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
  Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, … See abstract for full author list ➔ Sims R, et al. Nat Genet. 2017 Sep;49(9):1373-1384. doi: 10.1038/ng.3916. Epub 2017 Jul 17. Nat Genet. 2017. PMID: 28714976 Free PMC article.
• Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.
  Pandey RS, Kotredes KP, Sasner M, Howell GR, Carter GW. Pandey RS, et al. BMC Genomics. 2023 Apr 4;24(1):172. doi: 10.1186/s12864-023-09280-x. BMC Genomics. 2023. PMID: 37016304 Free PMC article.
• The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
  Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C. Xiang X, et al. Mol Neurodegener. 2018 Sep 6;13(1):49. doi: 10.1186/s13024-018-0280-6. Mol Neurodegener. 2018. PMID: 30185230 Free PMC article.
• TREM2 variants: new keys to decipher Alzheimer disease pathogenesis.
  Colonna M, Wang Y. Colonna M, et al. Nat Rev Neurosci. 2016 Apr;17(4):201-7. doi: 10.1038/nrn.2016.7. Epub 2016 Feb 25. Nat Rev Neurosci. 2016. PMID: 26911435 Review.
• What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?
  Lue LF, Schmitz C, Walker DG. Lue LF, et al. Neuroscience. 2015 Aug 27;302:138-50. doi: 10.1016/j.neuroscience.2014.09.050. Epub 2014 Oct 2. Neuroscience. 2015. PMID: 25281879 Review.