Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells - PubMed (original) (raw)
doi: 10.1038/ni.2665. Epub 2013 Jul 21.
Anil Kumar, Gan Siok Wan, Gundimeda S Ramanjaneyulu, Marco Cavallari, Sary El Daker, Travis Beddoe, Alex Theodossis, Neal K Williams, Emma Gostick, David A Price, Dinish U Soudamini, Kong Kien Voon, Malini Olivo, Jamie Rossjohn, Lucia Mori, Gennaro De Libero
Affiliations
- PMID: 23872678
- DOI: 10.1038/ni.2665
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells
Stefano Vavassori et al. Nat Immunol. 2013 Sep.
Abstract
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules. Here we used genetic approaches to identify the molecule that binds and presents phosphorylated antigens. We found that the butyrophilin BTN3A1 bound phosphorylated antigens with low affinity, at a stoichiometry of 1:1, and stimulated mouse T cells with transgenic expression of a human Vγ9Vδ2 TCR. The structures of the BTN3A1 distal domain in complex with host- or microbe-derived phosphorylated antigens had an immunoglobulin-like fold in which the antigens bound in a shallow pocket. Soluble Vγ9Vδ2 TCR interacted specifically with BTN3A1-antigen complexes. Accordingly, BTN3A1 represents an antigen-presenting molecule required for the activation of Vγ9Vδ2 T cells.
Comment in
- Resolving the mystery of pyrophosphate antigen presentation.
Willcox CR, Mohammed F, Willcox BE. Willcox CR, et al. Nat Immunol. 2013 Sep;14(9):886-7. doi: 10.1038/ni.2689. Nat Immunol. 2013. PMID: 23959177 No abstract available. - Critical role of butyrophilin 3A1 in presenting prenyl pyrophosphate antigens to human γδ T cells.
Kabelitz D. Kabelitz D. Cell Mol Immunol. 2014 Mar;11(2):117-9. doi: 10.1038/cmi.2013.50. Epub 2013 Oct 7. Cell Mol Immunol. 2014. PMID: 24097034 Free PMC article. No abstract available. - A fat story-antigen presentation by butyrophilin 3A1 to γδ T cells.
Esser C. Esser C. Cell Mol Immunol. 2014 Jan;11(1):5-7. doi: 10.1038/cmi.2013.46. Epub 2013 Oct 7. Cell Mol Immunol. 2014. PMID: 24097036 Free PMC article. No abstract available. - Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system.
Dieli F, Fadda R, Caccamo N. Dieli F, et al. Cell Mol Immunol. 2014 Mar;11(2):123-5. doi: 10.1038/cmi.2013.54. Epub 2013 Nov 25. Cell Mol Immunol. 2014. PMID: 24270471 Free PMC article. No abstract available.
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