Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems - PubMed (original) (raw)
Review
Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems
Lars Brichta et al. Trends Neurosci. 2013 Sep.
Abstract
For several decades, the dopamine precursor levodopa has been the primary therapy for Parkinson's disease (PD). However, not all of the motor and non-motor features of PD can be attributed solely to dopaminergic dysfunction. Recent clinical and preclinical advances provide a basis for the identification of additional innovative therapeutic options to improve the management of the disease. Novel pharmacological strategies must be optimized for PD by: (i) targeting disturbances of the serotonergic, noradrenergic, glutamatergic, GABAergic, and cholinergic systems in addition to the dopaminergic system, and (ii) characterizing alterations in the levels of neurotransmitter receptors and transporters that are associated with the various manifestations of the disease.
Keywords: GABA; Parkinson's disease; acetylcholine; basal ganglia; dopamine; glutamate; norepinephrine; serotonin; striatum; substantia nigra.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical