Creating a false memory in the hippocampus - PubMed (original) (raw)
. 2013 Jul 26;341(6144):387-91.
doi: 10.1126/science.1239073.
Affiliations
- PMID: 23888038
- DOI: 10.1126/science.1239073
Creating a false memory in the hippocampus
Steve Ramirez et al. Science. 2013.
Abstract
Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.
Comment in
- Shining a light on memory representations.
Saksida LM. Saksida LM. Trends Cogn Sci. 2013 Oct;17(10):486-7. doi: 10.1016/j.tics.2013.08.009. Epub 2013 Aug 28. Trends Cogn Sci. 2013. PMID: 23993678
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