γH2AX spreading linked to homology search - PubMed (original) (raw)

Editorial

. 2013 Aug 15;12(16):2526-7.

doi: 10.4161/cc.25836. Epub 2013 Jul 29.

• PMID: 23907159
• PMCID: PMC3865035
• DOI: 10.4161/cc.25836

Editorial

γH2AX spreading linked to homology search

Jörg Renkawitz et al. Cell Cycle. 2013.

No abstract available

Keywords: DNA repair; DSB; centromere; chromatin; chromosomal architecture; histone modification; homology search; nuclear organization; γH2A; γH2AX.

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Figures

Figure 1. γH2AX follows homology search. Homology search (depicted as black arrows) during homologous recombination can be monitored in vivo by Rad51-directed chromatin immunoprecipitations (ChIP). The profiles of ChIP signal distributions for γH2A (orange) and Rad51 (black) both follow homology search and only differ near the DSB because of histone eviction linked to resection (blue, ssDNA).

Comment on

• Monitoring homology search during DNA double-strand break repair in vivo.
  Renkawitz J, Lademann CA, Kalocsay M, Jentsch S. Renkawitz J, et al. Mol Cell. 2013 Apr 25;50(2):261-72. doi: 10.1016/j.molcel.2013.02.020. Epub 2013 Mar 21. Mol Cell. 2013. PMID: 23523370

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