The biology and clinical impact of genetic lesions in myeloid malignancies - PubMed (original) (raw)
Review
. 2013 Nov 28;122(23):3741-8.
doi: 10.1182/blood-2013-06-460295. Epub 2013 Aug 16.
Affiliations
- PMID: 23954890
- DOI: 10.1182/blood-2013-06-460295
Free article
Review
The biology and clinical impact of genetic lesions in myeloid malignancies
R Coleman Lindsley et al. Blood. 2013.
Free article
Abstract
A longstanding endeavor to define the genetic lesions that drive myeloid malignances has stimulated a period of remarkable discovery. Enabled by technological advances that have sharply decreased the cost of DNA sequencing, the full compendium of common, recurrent somatic mutations in the coding genome of myeloid malignancies is nearly complete. As the focus of genetic discovery shifts to the noncoding genome, renewed attention is being applied to the clinical and biological implications of recent genomic advances. Although the potential for this newfound knowledge to influence the care of patients has not yet been realized, broad genetic surveys of patient samples are now being used to improve the accuracy of disease diagnosis, define a molecular taxonomy of myeloid malignancies, refine prognostic and predictive models, and identify novel therapeutic strategies. Here, we will review recent advances in the genetics of myeloid malignancies and discuss their potential impact on clinical practice.
Similar articles
- Cohesin mutations in myeloid malignancies.
Jann JC, Tothova Z. Jann JC, et al. Blood. 2021 Aug 26;138(8):649-661. doi: 10.1182/blood.2019004259. Blood. 2021. PMID: 34157074 Free PMC article. Review. - Molecular genetic biomarkers in myeloid malignancies.
Matynia AP, Szankasi P, Shen W, Kelley TW. Matynia AP, et al. Arch Pathol Lab Med. 2015 May;139(5):594-601. doi: 10.5858/arpa.2014-0096-RA. Epub 2014 Aug 25. Arch Pathol Lab Med. 2015. PMID: 25152312 Review. - Diagnostic, Prognostic, and Predictive Utility of Recurrent Somatic Mutations in Myeloid Neoplasms.
Patel U, Luthra R, Medeiros LJ, Patel KP. Patel U, et al. Clin Lymphoma Myeloma Leuk. 2017 Jul;17S:S62-S74. doi: 10.1016/j.clml.2017.02.015. Clin Lymphoma Myeloma Leuk. 2017. PMID: 28760304 Review. - The genomic landscape of myeloid neoplasms with myelodysplasia and its clinical implications.
Malcovati L, Ambaglio I, Elena C. Malcovati L, et al. Curr Opin Oncol. 2015 Nov;27(6):551-9. doi: 10.1097/CCO.0000000000000229. Curr Opin Oncol. 2015. PMID: 26352542 Review. - Prognostic significance of del(20q) in patients with hematological malignancies.
Brezinová J, Zemanová Z, Ransdorfová S, Sindelárová L, Sisková M, Neuwirtová R, Cermák J, Michalová K. Brezinová J, et al. Cancer Genet Cytogenet. 2005 Jul 15;160(2):188-92. doi: 10.1016/j.cancergencyto.2004.12.019. Cancer Genet Cytogenet. 2005. PMID: 15993278
Cited by
- Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.
Ghashghaei M, Liu Y, Ettles J, Bombaci G, Ramkumar N, Liu Z, Escano L, Miko SS, Kim Y, Waldron JA, Do K, MacPherson K, Yuen KA, Taibi T, Yue M, Arsalan A, Jin Z, Edin G, Karsan A, Morin GB, Kuchenbauer F, Perna F, Bushell M, Vu LP. Ghashghaei M, et al. Nat Commun. 2024 Mar 15;15(1):2340. doi: 10.1038/s41467-024-46665-2. Nat Commun. 2024. PMID: 38491013 Free PMC article. - Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation.
Chen PY, Huang BJ, Harris M, Boone C, Wang W, Carias H, Mesiona B, Mavrici D, Kohler AC, Bollag G, Zhang C, Zhang Y, Shannon K. Chen PY, et al. JCI Insight. 2023 Sep 8;8(17):e168445. doi: 10.1172/jci.insight.168445. JCI Insight. 2023. PMID: 37681415 Free PMC article. - Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change.
Erenpreisa J, Giuliani A, Yoshikawa K, Falk M, Hildenbrand G, Salmina K, Freivalds T, Vainshelbaum N, Weidner J, Sievers A, Pilarczyk G, Hausmann M. Erenpreisa J, et al. Int J Mol Sci. 2023 Jan 31;24(3):2658. doi: 10.3390/ijms24032658. Int J Mol Sci. 2023. PMID: 36769000 Free PMC article. Review. - Extracellular Vesicles in Myeloid Neoplasms.
Karantanou C, Minciacchi VR, Karantanos T. Karantanou C, et al. Int J Mol Sci. 2022 Aug 8;23(15):8827. doi: 10.3390/ijms23158827. Int J Mol Sci. 2022. PMID: 35955960 Free PMC article. Review. - Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia.
Wei Y, Kanagal-Shamanna R, Zheng H, Bao N, Lockyer PP, Class CA, Darbaniyan F, Lu Y, Lin K, Yang H, Montalban-Bravo G, Ganan-Gomez I, Soltysiak KA, Do KA, Colla S, Garcia-Manero G. Wei Y, et al. Leukemia. 2022 Aug;36(8):2097-2107. doi: 10.1038/s41375-022-01605-1. Epub 2022 Jun 14. Leukemia. 2022. PMID: 35697791
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials