Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens - PubMed (original) (raw)

Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens

S Szala et al. Proc Natl Acad Sci U S A. 1990 Sep.

Abstract

The human tumor-associated antigen CO-029 is a monoclonal antibody-defined cell surface glycoprotein of 27-34 kDa. By using the high-efficiency COS cell expression system, a full-length cDNA clone for CO-029 was isolated. When transiently expressed in COS cells, the cDNA clone directed the synthesis of an antigen reactive to monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis revealed that CO-029 belongs to a family of cell surface antigens that includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni. CO-029 and ME491 antigen expression and the effect of their corresponding monoclonal antibodies on cell growth were compared in human tumor cell lines of various histologic origins.

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References

1. 1. Cancer Res. 1980 Oct;40(10):3602-9 - PubMed
2. 1. Arch Biochem Biophys. 1989 Jun;271(2):366-79 - PubMed
3. 1. Methods Enzymol. 1983;91:524-45 - PubMed
4. 1. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 - PubMed
5. 1. J Immunol Methods. 1984 Oct 12;73(1):157-67 - PubMed

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