Endogenously generated and visually guided saccades after lesions of the human frontal eye fields - PubMed (original) (raw)
Endogenously generated and visually guided saccades after lesions of the human frontal eye fields
A Henik et al. J Cogn Neurosci. 1994 Fall.
Abstract
Abstract Nine patients with chronic, unilateral lesions of the dorso-lateral prefrontal cortex including the frontal eye fields (FEF) made saccades toward contralesional and ipsilesional fields. The saccades were either voluntarily directed in response to arrows in the center of a visual display, or were reflexively summoned by a peripheral visual signal. Saccade latencies were compared to those made by seven neurologic control patients with chronic, unilateral lesions of dorsolateral prefrontal cortex sparing the FEF, and by 13 normal control subjects. In both the normal and neurologic control subjects, reflexive saccades had shorter Latencies than voluntary saccades. In the FEF lesion patients, voluntary saccades had longer latencies toward the contralesional field than toward the ipsilesional field. The opposite pattern was found for reflexive saccades: latencies of saccades to targets in the contralesional field were shorter than saccades summoned to ipsilesional targets. Reflexive saccades toward the ipsilesional field had abnormally prolonged latencies; they were comparable to the latencies observed for voluntary Saccades. The effect of FEF lesions on saccacles contrasted with those observed in a second experiment requiring a key press response: FEF lesion patients were slower in making key press responses to signals detected in the contralesional field. To assess covert attention and preparatory set the effects of precues providing advance information were measured in both saccade and key press experiments. Neither patient group showed any deficiency in using precues to shift attention or to prepare saccades. The FEF facilitates the generation of voluntary saccatles and also inhibits reflexive saccades to exogenous signals. FEF lesions may disinhibit the ipsilesional midbrain which in turn may inhibit the opposite colliculus to slow reflexive saccades toward the ipsilesional field.
Similar articles
- Control of fixation and saccades during an anti-saccade task: an investigation in humans with chronic lesions of oculomotor cortex.
Machado L, Rafal RD. Machado L, et al. Exp Brain Res. 2004 May;156(1):55-63. doi: 10.1007/s00221-003-1765-1. Epub 2003 Dec 18. Exp Brain Res. 2004. PMID: 14685809 - Oculomotor functions of the parietal lobe: Effects of chronic lesions in humans.
Rafal RD. Rafal RD. Cortex. 2006 Jul;42(5):730-9. doi: 10.1016/s0010-9452(08)70411-8. Cortex. 2006. PMID: 16909633 Review. - The role of the frontal eye fields in the oculomotor inhibition of reflexive saccades: evidence from lesion patients.
Van der Stigchel S, van Koningsbruggen M, Nijboer TC, List A, Rafal RD. Van der Stigchel S, et al. Neuropsychologia. 2012 Jan;50(1):198-203. doi: 10.1016/j.neuropsychologia.2011.11.020. Epub 2011 Dec 6. Neuropsychologia. 2012. PMID: 22155181 - Saccade abnormalities associated with focal cerebral lesions - How cortical and basal ganglia commands shape saccades in humans.
Terao Y, Fukuda H, Tokushuge S, Nomura Y, Hanajima R, Ugawa Y. Terao Y, et al. Clin Neurophysiol. 2016 Aug;127(8):2953-2967. doi: 10.1016/j.clinph.2015.07.041. Epub 2015 Sep 30. Clin Neurophysiol. 2016. PMID: 26475210 - Neural mechanisms underlying target selection with saccadic eye movements.
Schiller PH, Tehovnik EJ. Schiller PH, et al. Prog Brain Res. 2005;149:157-71. doi: 10.1016/S0079-6123(05)49012-3. Prog Brain Res. 2005. PMID: 16226583 Review.
Cited by
- Seeing without a Scene: Neurological Observations on the Origin and Function of the Dorsal Visual Stream.
Rafal RD. Rafal RD. J Intell. 2024 May 11;12(5):50. doi: 10.3390/jintelligence12050050. J Intell. 2024. PMID: 38786652 Free PMC article. - Spontaneous perception: a framework for task-free, self-paced perception.
Baror S, He BJ. Baror S, et al. Neurosci Conscious. 2021 Aug 4;2021(2):niab016. doi: 10.1093/nc/niab016. eCollection 2021. Neurosci Conscious. 2021. PMID: 34377535 Free PMC article. Review. - Attentional bias towards negative stimuli in healthy individuals and the effects of trait anxiety.
Veerapa E, Grandgenevre P, El Fayoumi M, Vinnac B, Haelewyn O, Szaffarczyk S, Vaiva G, D'Hondt F. Veerapa E, et al. Sci Rep. 2020 Jul 16;10(1):11826. doi: 10.1038/s41598-020-68490-5. Sci Rep. 2020. PMID: 32678129 Free PMC article. - The Effect of Stimulus Size and Eccentricity on Attention Shift Latencies.
Kulke L. Kulke L. Vision (Basel). 2017 Dec 7;1(4):25. doi: 10.3390/vision1040025. Vision (Basel). 2017. PMID: 31740650 Free PMC article. - Attention Combines Similarly in Covert and Overt Conditions.
Blair CD, Ristic J. Blair CD, et al. Vision (Basel). 2019 Apr 25;3(2):16. doi: 10.3390/vision3020016. Vision (Basel). 2019. PMID: 31735817 Free PMC article.
LinkOut - more resources
Full Text Sources