Pathology of experimental autoimmune uveoretinitis in mice - PubMed (original) (raw)
Pathology of experimental autoimmune uveoretinitis in mice
C C Chan et al. J Autoimmun. 1990 Jun.
Abstract
The histopathology and immunopathology of murine experimental autoimmune uveoretinitis (EAU) following active immunization with the interphotoreceptor retinoid-binding protein (IRBP) were studied. The methods used included conventional light microscopy and immunoperoxidase staining. Lesions were located mainly in the uvea and the retina and were characteristically focal. The prominent histopathologic findings in the retina were vasculitis, granuloma, retinal fold, focal serous detachment, and loss of photoreceptors. Granulomas, formation of Dalen-Fuchs nodules, inflammatory cellular infiltration and increase in the thickness of the choroid and ciliary body were frequent findings. Subretinal neovascularization occurred in 10% of the experimental animals. Mild to moderate inflammation was also noted in the vitreous. The predominant infiltrating cells in the retinal and uveal granuloma and the Dalen-Fuchs nodules were macrophages. In contrast, the predominant infiltrating cell types in the vitreous were T helper/inducer lymphocytes. T suppressor/cytotoxic cells were rarely seen. Expression of Ia antigens on the ocular cells was confined to the immediate area of the inflammatory sites. The kinetics of histopathology showed two peaks at the 5th and 10th week after immunization, suggesting a relapsing course of the disease.
Similar articles
- Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice.
Jiang HR, Lumsden L, Forrester JV. Jiang HR, et al. Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3177-85. Invest Ophthalmol Vis Sci. 1999. PMID: 10586940 - Immunohistochemical analysis of experimental autoimmune uveoretinitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) in the rat.
Chan CC, Nussenblatt RB, Wiggert B, Redmond TM, Fujikawa LS, Chader GJ, Gery I. Chan CC, et al. Immunol Invest. 1987 Mar;16(1):63-74. doi: 10.3109/08820138709055713. Immunol Invest. 1987. PMID: 3497100 - Angiography of experimental autoimmune uveoretinitis with ultrastructural correlation.
Okada AA, Goto H, Mizusawa T, Morimoto K, Ebihara Y, Usui M. Okada AA, et al. Graefes Arch Clin Exp Ophthalmol. 1998 Nov;236(11):865-72. doi: 10.1007/s004170050172. Graefes Arch Clin Exp Ophthalmol. 1998. PMID: 9825263 - A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens.
Caspi RR, Roberge FG, Chan CC, Wiggert B, Chader GJ, Rozenszajn LA, Lando Z, Nussenblatt RB. Caspi RR, et al. J Immunol. 1988 Mar 1;140(5):1490-5. J Immunol. 1988. PMID: 3346541 - Resident and infiltrating immune cells in the uveal tract in the early and late stages of experimental autoimmune uveoretinitis.
Butler TL, McMenamin PG. Butler TL, et al. Invest Ophthalmol Vis Sci. 1996 Oct;37(11):2195-210. Invest Ophthalmol Vis Sci. 1996. PMID: 8843906
Cited by
- FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis.
He S, Li W, Wang G, Wang X, Fan W, Zhang Z, Li N, Hou S. He S, et al. Genes Dis. 2022 Oct 4;10(5):2179-2193. doi: 10.1016/j.gendis.2022.09.008. eCollection 2023 Sep. Genes Dis. 2022. PMID: 37492748 Free PMC article. - IL-27-containing exosomes secreted by innate B-1a cells suppress and ameliorate uveitis.
Kang M, Yadav MK, Mbanefo EC, Yu CR, Egwuagu CE. Kang M, et al. Front Immunol. 2023 Jun 2;14:1071162. doi: 10.3389/fimmu.2023.1071162. eCollection 2023. Front Immunol. 2023. PMID: 37334383 Free PMC article. - Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation.
Gonzalez-Fierro C, Fonte C, Dufourd E, Cazaentre V, Aydin S, Engelhardt B, Caspi RR, Xu B, Martin-Blondel G, Spicer JA, Trapani JA, Bauer J, Liblau RS, Bost C. Gonzalez-Fierro C, et al. Neurol Neuroimmunol Neuroinflamm. 2023 Apr 20;10(4):e200117. doi: 10.1212/NXI.0000000000200117. Print 2023 Jul. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37080596 Free PMC article. - Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege.
Yu CR, Yadav MK, Kang M, Jittayasothorn Y, Dong L, Egwuagu CE. Yu CR, et al. Int J Mol Sci. 2022 Jul 24;23(15):8156. doi: 10.3390/ijms23158156. Int J Mol Sci. 2022. PMID: 35897732 Free PMC article. - A Novel Tree Shrew Model of Chronic Experimental Autoimmune Uveitis and Its Disruptive Application.
Hu K, Lv L, Huang H, Yin G, Gao J, Liu J, Yang Y, Zeng W, Chen Y, Zhang N, Zhang F, Ma Y, Chen F. Hu K, et al. Front Immunol. 2022 May 27;13:889596. doi: 10.3389/fimmu.2022.889596. eCollection 2022. Front Immunol. 2022. PMID: 35711454 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical