BLT2 is a pro-tumorigenic mediator during cancer progression and a therapeutic target for anti-cancer drug development - PubMed (original) (raw)

. 2013 Aug 14;3(4):347-55.

eCollection 2013.

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BLT2 is a pro-tumorigenic mediator during cancer progression and a therapeutic target for anti-cancer drug development

Nam-Kyu Cho et al. Am J Cancer Res. 2013.

Abstract

Cancer is a leading cause of death worldwide and has been linked to inflammation. Leukotriene B4 (LTB4) is synthesized from arachidonic acid via the 5-lipoxygenase pathway and is a potent chemoattractant for inflammatory cells. LTB4 was recently shown to be associated with the pathogenesis of inflammatory diseases, including cancer. Of the two known LTB4 receptors, BLT1 and BLT2, the biological roles of the low-affinity LTB4 receptor 2, BLT2, have only recently been elucidated. This review focuses on recent discoveries regarding BLT2 and its roles in cancer progression and the downstream signaling mechanisms of the BLT2-linked signaling cascade in cancer cells. We believe that these findings will facilitate the development of new cancer treatments.

Keywords: Leukotriene B4 receptor 2 (BLT2); NADPH oxidase; cancer progression; leukotriene B4; nuclear factor-kB; reactive oxygen species.

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Figures

Figure 1

Figure 1

Schematic of LTB4 Biosynthesis. When a cell is activated, the increase in the intracellular Ca2+ concentration triggers the translocation of cPLA2 and 5-LOX to the nuclear membrane. Free arachidonic acid released by cPLA2 is metabolized to LTA4 and LTB4 via 5-LOX and LTA4H, respectively.

Figure 2

Figure 2

A Comprehensive Overview of BLT2 Signaling Pathways. For details, see text.

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