Flavonoids from Sudanese Albizia zygia (Leguminosae, subfamily Mimosoideae), a plant with antimalarial potency - PubMed (original) (raw)

Flavonoids from Sudanese Albizia zygia (Leguminosae, subfamily Mimosoideae), a plant with antimalarial potency

Muna Ali Abdalla et al. Afr J Tradit Complement Altern Med. 2011.

Abstract

Three flavonoids were isolated for the first time from the Sudanese medicinal plants Albizia zygia. Compounds 1-3 were identified by interpretation of ESI mass data, (1)H, (13)C and 2D NMR as well as by comparison with published data as 4',7-dihydroxyflavanone (1) 3',4',7-trihydroxyflavone (2), 3-O-methylfisetin (3',4',7-trihydroxy-3-methoxyflavone, 3). All flavonoids were tested against Plasmodium falciparum, and only compound 2 showed high antimalarial activity (IC50 0.078 µg/ml).

Keywords: Albizia zygia; Mimosoideae; antimalarial activity; flavonoids.

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References

1. 1. Ajay KD, Laxmi NM. Macrocyclic budmunchiamine alkaloids from Albizia lebbek. J Nat Prod. 1997;60:1036–1037.
2. 1. Arthur CH, Brookes KB, Bull JR, McGarry EJ, McGarry JM. Flavonoids of Albizia adianthifolia. Phytochemistry. 1978;17:1681–1682.
3. 1. Ashton WR, Jefferies M, Morley RG, Pass G, Phillips GO, Power DM. Physical properties and applications of aqueous solutions of African Albizia zygia gum. J Sci Food Agric. 1975;26:697–704.
4. 1. Blair JA, Ongley PA, Chiswell J, Griffiths MHG. Isolation of lupeol from the bark of Heritiera utilis (Tarrietia utilis) Phytochemistry. 1970;9:671.
5. 1. De Almeida Alves TM, Nagem TJ, de Carvalho LZ, Krettli AU, Zani CL. Anti-plasmodial triterpene from Vernonia brasiliana. Planta Med. 1997;63:554–555. - PubMed

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